An acute eccentric exercise increases circulating myomesin 3 fragments

Minjung Lee; Jaehoon Shin; Tatsuya Kato; Kazue Kanda; Satoshi Oikawa; Jun Sakuma; Kaoru Sugama; Yasuo Kawakami; Katsuhiko Suzuki; Takayuki Akimoto

doi:10.1186/s12576-021-00789-y

An acute eccentric exercise increases circulating myomesin 3 fragments

Minjung Lee, Jaehoon Shin, Tatsuya Kato, Kazue Kanda, Satoshi Oikawa, Jun Sakuma, Kaoru Sugama, Yasuo Kawakami, Katsuhiko Suzuki, Takayuki Akimoto

School of Sport Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Discovery of blood biomarkers to evaluate exercise-induced muscle damage have attracted many researchers and coaches. This study aimed to determine changes in circulating myomesin 3 fragments as a novel biomarker for exercise-induced muscle damage. Nine healthy males performed 10 sets of 40 repetitions of one-leg calf-raise exercise by the load corresponding to the half of their body weight. Muscle symptoms were evaluated by a visual analog scale (VAS). Blood samples were collected before and 2, 4, 24, 48, 72, and 96 h post-exercise. Plasma myomesin 3 fragments levels were significantly increased at 96 h after the eccentric exercise. The myomesin 3 fragments levels were correlated with other biomarkers of muscle damage and the muscle symptoms. These results suggest that the circulating myomesin 3 fragments levels are potential biomarkers reflecting eccentric exercise-induced muscle damage.

Original language	English
Article number	4
Journal	Journal of Physiological Sciences
Volume	71
Issue number	1
DOIs	https://doi.org/10.1186/s12576-021-00789-y
Publication status	Published - 2021 Dec

Keywords

Biomarkers
Eccentric exercise
Muscle damage
Myomesin

ASJC Scopus subject areas

Physiology

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title = "An acute eccentric exercise increases circulating myomesin 3 fragments",

abstract = "Discovery of blood biomarkers to evaluate exercise-induced muscle damage have attracted many researchers and coaches. This study aimed to determine changes in circulating myomesin 3 fragments as a novel biomarker for exercise-induced muscle damage. Nine healthy males performed 10 sets of 40 repetitions of one-leg calf-raise exercise by the load corresponding to the half of their body weight. Muscle symptoms were evaluated by a visual analog scale (VAS). Blood samples were collected before and 2, 4, 24, 48, 72, and 96 h post-exercise. Plasma myomesin 3 fragments levels were significantly increased at 96 h after the eccentric exercise. The myomesin 3 fragments levels were correlated with other biomarkers of muscle damage and the muscle symptoms. These results suggest that the circulating myomesin 3 fragments levels are potential biomarkers reflecting eccentric exercise-induced muscle damage.",

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note = "Funding Information: This study was supported in part by Grants-in-Aid for Scientific Research (B) (21300217 to YK) from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and Total conditioning research project (to TA) from Japan Sports Council. ML was supported by the Japan Society for the Promotion of Science. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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doi = "10.1186/s12576-021-00789-y",

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AU - Lee, Minjung

AU - Shin, Jaehoon

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AU - Oikawa, Satoshi

AU - Sakuma, Jun

AU - Sugama, Kaoru

AU - Kawakami, Yasuo

AU - Suzuki, Katsuhiko

AU - Akimoto, Takayuki

N1 - Funding Information: This study was supported in part by Grants-in-Aid for Scientific Research (B) (21300217 to YK) from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and Total conditioning research project (to TA) from Japan Sports Council. ML was supported by the Japan Society for the Promotion of Science. Publisher Copyright: © 2021, The Author(s).

PY - 2021/12

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N2 - Discovery of blood biomarkers to evaluate exercise-induced muscle damage have attracted many researchers and coaches. This study aimed to determine changes in circulating myomesin 3 fragments as a novel biomarker for exercise-induced muscle damage. Nine healthy males performed 10 sets of 40 repetitions of one-leg calf-raise exercise by the load corresponding to the half of their body weight. Muscle symptoms were evaluated by a visual analog scale (VAS). Blood samples were collected before and 2, 4, 24, 48, 72, and 96 h post-exercise. Plasma myomesin 3 fragments levels were significantly increased at 96 h after the eccentric exercise. The myomesin 3 fragments levels were correlated with other biomarkers of muscle damage and the muscle symptoms. These results suggest that the circulating myomesin 3 fragments levels are potential biomarkers reflecting eccentric exercise-induced muscle damage.

AB - Discovery of blood biomarkers to evaluate exercise-induced muscle damage have attracted many researchers and coaches. This study aimed to determine changes in circulating myomesin 3 fragments as a novel biomarker for exercise-induced muscle damage. Nine healthy males performed 10 sets of 40 repetitions of one-leg calf-raise exercise by the load corresponding to the half of their body weight. Muscle symptoms were evaluated by a visual analog scale (VAS). Blood samples were collected before and 2, 4, 24, 48, 72, and 96 h post-exercise. Plasma myomesin 3 fragments levels were significantly increased at 96 h after the eccentric exercise. The myomesin 3 fragments levels were correlated with other biomarkers of muscle damage and the muscle symptoms. These results suggest that the circulating myomesin 3 fragments levels are potential biomarkers reflecting eccentric exercise-induced muscle damage.

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An acute eccentric exercise increases circulating myomesin 3 fragments

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Keywords

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