An artificial myocardium assist system

Electrohydraulic ventricular actuation improves myocardial tissue perfusion in goats

Qingtian Wang, Tomoyuki Yambe, Yasuyuki Shiraishi, Xudong Duan, Shinichi Nitta, Kouichi Tabayashi, Mitsuo Umezu

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    Artificial hearts and ventricular assist devices have been widely used clinically to assist patients with severe heart failure. Unfortunately, direct contact between the device and the patient's blood leads to thromboembolic events, and then the need for anticoagulation and infections contribute significantly to complication and mortality. Compressing the dysfunctional heart from its epicardial surface, a nonblood-contacting method of direct mechanical ventricular actuation could provide ventricular support, pulsatile blood flow, and avoid interactions between blood and the surface of the artificial assistance system. An ElectroHydraulic Artificial Myocardial (EHAM) assist system that might assist heart muscle contraction has been developed. The purpose of this study is to determine the efficiency of the EHAM system in perfusing myocardial tissue in an acute animal experiment. Method: Healthy adult goats (n = 8) were used in acute animal experiments. A left lateral thoracotomy was done and the chest was opened through the 4th and 5th rib resection. Hemodynamic parameters were continuously monitored including ECG, aortic blood pressure, left ventricular pressure, and pulmonary artery pressure. Myocardial tissue perfusion was measured by using an Omega flow laser fiber attached on the surface of the heart. Results: All the animals achieved significantly increased blood pressure, pulmonary artery flow, and myocardial tissue perfusion during the EHAM compression compared with the nondriving (pre-assisted) mode. Conclusions: The EHAM system can effectively improve myocardial tissue perfusion and increase blood pressure thus demonstrating a potential for treating failing cardiac performance.

    Original languageEnglish
    Pages (from-to)853-857
    Number of pages5
    JournalArtificial Organs
    Volume28
    Issue number9
    DOIs
    Publication statusPublished - 2004 Sep

    Fingerprint

    Goats
    Myocardium
    Blood pressure
    Perfusion
    Tissue
    Animals
    Heart-Assist Devices
    Blood
    Pulmonary Artery
    Blood Pressure
    Artificial heart
    Artificial Heart
    Blood Substitutes
    Pulsatile Flow
    Hemodynamics
    Ribs
    Ventricular Pressure
    Thoracotomy
    Fiber lasers
    Muscle Contraction

    Keywords

    • Artificial heart
    • Artificial myocardium
    • Myocardial perfusion
    • Ventricular actuator

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    An artificial myocardium assist system : Electrohydraulic ventricular actuation improves myocardial tissue perfusion in goats. / Wang, Qingtian; Yambe, Tomoyuki; Shiraishi, Yasuyuki; Duan, Xudong; Nitta, Shinichi; Tabayashi, Kouichi; Umezu, Mitsuo.

    In: Artificial Organs, Vol. 28, No. 9, 09.2004, p. 853-857.

    Research output: Contribution to journalArticle

    Wang, Qingtian ; Yambe, Tomoyuki ; Shiraishi, Yasuyuki ; Duan, Xudong ; Nitta, Shinichi ; Tabayashi, Kouichi ; Umezu, Mitsuo. / An artificial myocardium assist system : Electrohydraulic ventricular actuation improves myocardial tissue perfusion in goats. In: Artificial Organs. 2004 ; Vol. 28, No. 9. pp. 853-857.
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