An enantioselective approach to (-)-platencin via catalytic asymmetric intramolecular cyclopropanation

Sho Hirai, Masahisa Nakada*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

This Letter describes an enantioselective approach to (-)-platencin. A uniquely functionalized chiral intermediate, which was prepared via the highly enantioselective catalytic asymmetric intramolecular cyclopropanation (CAIMCP) that we have developed, was successfully transformed to Nicolaou's intermediate in his total synthesis of (-)-platencin.

Original languageEnglish
Pages (from-to)5076-5079
Number of pages4
JournalTetrahedron Letters
Volume51
Issue number38
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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