An enantioselective approach to (-)-platencin via catalytic asymmetric intramolecular cyclopropanation

Sho Hirai; Masahisa Nakada

doi:10.1016/j.tetlet.2010.07.088

An enantioselective approach to (-)-platencin via catalytic asymmetric intramolecular cyclopropanation

Sho Hirai, Masahisa Nakada

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

This Letter describes an enantioselective approach to (-)-platencin. A uniquely functionalized chiral intermediate, which was prepared via the highly enantioselective catalytic asymmetric intramolecular cyclopropanation (CAIMCP) that we have developed, was successfully transformed to Nicolaou's intermediate in his total synthesis of (-)-platencin.

Original language	English
Pages (from-to)	5076-5079
Number of pages	4
Journal	Tetrahedron Letters
Volume	51
Issue number	38
DOIs	https://doi.org/10.1016/j.tetlet.2010.07.088
Publication status	Published - 2010

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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abstract = "This Letter describes an enantioselective approach to (-)-platencin. A uniquely functionalized chiral intermediate, which was prepared via the highly enantioselective catalytic asymmetric intramolecular cyclopropanation (CAIMCP) that we have developed, was successfully transformed to Nicolaou's intermediate in his total synthesis of (-)-platencin.",

author = "Sho Hirai and Masahisa Nakada",

note = "Funding Information: This work was financially supported in part by a Waseda University Grant for the Special Research Projects, a Grant-in-Aid for Scientific Research on Innovative Areas (No. 21106009), and the Global COE program {\textquoteleft}Center for Practical Chemical Wisdom{\textquoteright} by MEXT . ",

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AU - Hirai, Sho

AU - Nakada, Masahisa

N1 - Funding Information: This work was financially supported in part by a Waseda University Grant for the Special Research Projects, a Grant-in-Aid for Scientific Research on Innovative Areas (No. 21106009), and the Global COE program ‘Center for Practical Chemical Wisdom’ by MEXT .

PY - 2010

Y1 - 2010

N2 - This Letter describes an enantioselective approach to (-)-platencin. A uniquely functionalized chiral intermediate, which was prepared via the highly enantioselective catalytic asymmetric intramolecular cyclopropanation (CAIMCP) that we have developed, was successfully transformed to Nicolaou's intermediate in his total synthesis of (-)-platencin.

AB - This Letter describes an enantioselective approach to (-)-platencin. A uniquely functionalized chiral intermediate, which was prepared via the highly enantioselective catalytic asymmetric intramolecular cyclopropanation (CAIMCP) that we have developed, was successfully transformed to Nicolaou's intermediate in his total synthesis of (-)-platencin.

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