An enantioselective Baylis-Hillman reaction catalyzed by chiral phosphines under atmospheric pressure

Tadakatsu Hayase, Takanori Shibata, Kenso Soai, Yasuo Wakatsuki

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl (BINAP) catalyzes the enantioselective Baylis-Hillman reaction between pyrimidine- 5-carbaldehydes and acrylates to provide chiral α-methylene ß-hydroxy esters in up to 44% ee under atmospheric pressure.

Original languageEnglish
Pages (from-to)1271-1272
Number of pages2
JournalChemical Communications
Issue number12
Publication statusPublished - 1998 Jun 21
Externally publishedYes

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Acrylates
Phosphines
Atmospheric pressure
Esters
2-naphthol BINAP
pyrimidine

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

An enantioselective Baylis-Hillman reaction catalyzed by chiral phosphines under atmospheric pressure. / Hayase, Tadakatsu; Shibata, Takanori; Soai, Kenso; Wakatsuki, Yasuo.

In: Chemical Communications, No. 12, 21.06.1998, p. 1271-1272.

Research output: Contribution to journalArticle

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