An enzyme logic bioprotonic transducer

Takeo Miyake, Erik E. Josberger, Scott Keene, Yingxin Deng, Marco Rolandi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Translating ionic currents into measureable electronic signals is essential for the integration of bioelectronic devices with biological systems. We demonstrate the use of a Pd/PdHx electrode as a bioprotonic transducer that connects H+ currents in solution into an electronic signal. This transducer exploits the reversible formation of PdHx in solution according to PdH虠Pd + H+ + e-, and the dependence of this formation on solution pH and applied potential. We integrate the protonic transducer with glucose dehydrogenase as an enzymatic and gate for glucose and NAD+. PdHx formation and associated electronic current monitors the output drop in pH, thus transducing a biological function into a measurable electronic output.

Original languageEnglish
Article number014906
JournalAPL Materials
Volume3
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes

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Transducers
Enzymes
Glucose
Glucose 1-Dehydrogenase
Biological systems
NAD
Electrodes
Oxidoreductases

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)

Cite this

Miyake, T., Josberger, E. E., Keene, S., Deng, Y., & Rolandi, M. (2015). An enzyme logic bioprotonic transducer. APL Materials, 3(1), [014906]. https://doi.org/10.1063/1.4900886

An enzyme logic bioprotonic transducer. / Miyake, Takeo; Josberger, Erik E.; Keene, Scott; Deng, Yingxin; Rolandi, Marco.

In: APL Materials, Vol. 3, No. 1, 014906, 01.01.2015.

Research output: Contribution to journalArticle

Miyake, T, Josberger, EE, Keene, S, Deng, Y & Rolandi, M 2015, 'An enzyme logic bioprotonic transducer', APL Materials, vol. 3, no. 1, 014906. https://doi.org/10.1063/1.4900886
Miyake T, Josberger EE, Keene S, Deng Y, Rolandi M. An enzyme logic bioprotonic transducer. APL Materials. 2015 Jan 1;3(1). 014906. https://doi.org/10.1063/1.4900886
Miyake, Takeo ; Josberger, Erik E. ; Keene, Scott ; Deng, Yingxin ; Rolandi, Marco. / An enzyme logic bioprotonic transducer. In: APL Materials. 2015 ; Vol. 3, No. 1.
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