An implantable centrifugal blood pump for long term circulatory support

Kenji Yamazaki, Philip Litwak, Robert L. Kormos, Toshio Mori, Osamu Tagusari, James F. Antaki, Marina Kameneva, Mary Watach, Lisa Gordon, Mitsuo Umezu, Jun Tomioka, Hitoshi Koyanagi, Bartley P. Griffith

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Abstract

    A compact centrifugal blood pump was developed as an implantable left ventricular assist system. The impeller diameter is 40 mm and the pump dimensions are 55 X 64 mm. This first prototype was fabricated from titanium alloy, resulting in a pump weight of 400 g including a brushless DC motor. Weight of the second prototype pump was reduced to 200 g. The entire blood contacting surface is coated with diamond like carbon to improve blood compatibility. Flow rates of over 7 L/min against 100 mmHg pressure at 2,500 rpm with 9 W total power consumption have been measured. A newly designed mechanical seal with a recirculating purge system ('Cool-Seal') is used as a shaft seat. In this seat system, seat temperature is kept under 40°C to prevent heat denaturation of blood proteins. Purge fluid also cools the pump motor coil and journal bearing. The purge fluid is continuously purified and sterilized by an ultrafiltration filter incorporated into the paracorporeal drive console. In vitro experiments with bovine blood demonstrated an acceptably low hemolysis rate (normalized index of hemolysis = 0.005 ± 0.002 g/100 L). In vivo experiments are currently ongoing using calves. Via left thoracotomy, left ventricular apex-descending aorta bypass was performed utilizing a PTFE (Polytetrafluoroethylene) vascular graft, with the pump placed in the left thoracic cavity. In two in vivo experiments, pump flow rate was maintained at 5-8 L/min, and pump power consumption remained stable at 9-10 W. All plasma free hemoglobin levels were measured at <15 mg/dl. The seal system has demonstrated good seal capability with negligible purge fluid consumption (<0.5 ml/day). Both animals remain under observation after 162 and 91 days of continuous pump function.

    Original languageEnglish
    JournalASAIO Journal
    Volume43
    Issue number5
    DOIs
    Publication statusPublished - 1997 Sep

    Fingerprint

    Blood
    Pumps
    Hemolysis
    Seals
    Seats
    Thoracic Cavity
    Weights and Measures
    Diamond
    Ultrafiltration
    Polytetrafluoroethylene
    Thoracotomy
    Titanium
    Thoracic Aorta
    Blood Vessels
    Blood Proteins
    Hemoglobins
    Fluids
    Carbon
    Hot Temperature
    Observation

    ASJC Scopus subject areas

    • Biophysics
    • Bioengineering

    Cite this

    Yamazaki, K., Litwak, P., Kormos, R. L., Mori, T., Tagusari, O., Antaki, J. F., ... Griffith, B. P. (1997). An implantable centrifugal blood pump for long term circulatory support. ASAIO Journal, 43(5). https://doi.org/10.1097/00002480-199709000-00072

    An implantable centrifugal blood pump for long term circulatory support. / Yamazaki, Kenji; Litwak, Philip; Kormos, Robert L.; Mori, Toshio; Tagusari, Osamu; Antaki, James F.; Kameneva, Marina; Watach, Mary; Gordon, Lisa; Umezu, Mitsuo; Tomioka, Jun; Koyanagi, Hitoshi; Griffith, Bartley P.

    In: ASAIO Journal, Vol. 43, No. 5, 09.1997.

    Research output: Contribution to journalArticle

    Yamazaki, K, Litwak, P, Kormos, RL, Mori, T, Tagusari, O, Antaki, JF, Kameneva, M, Watach, M, Gordon, L, Umezu, M, Tomioka, J, Koyanagi, H & Griffith, BP 1997, 'An implantable centrifugal blood pump for long term circulatory support', ASAIO Journal, vol. 43, no. 5. https://doi.org/10.1097/00002480-199709000-00072
    Yamazaki K, Litwak P, Kormos RL, Mori T, Tagusari O, Antaki JF et al. An implantable centrifugal blood pump for long term circulatory support. ASAIO Journal. 1997 Sep;43(5). https://doi.org/10.1097/00002480-199709000-00072
    Yamazaki, Kenji ; Litwak, Philip ; Kormos, Robert L. ; Mori, Toshio ; Tagusari, Osamu ; Antaki, James F. ; Kameneva, Marina ; Watach, Mary ; Gordon, Lisa ; Umezu, Mitsuo ; Tomioka, Jun ; Koyanagi, Hitoshi ; Griffith, Bartley P. / An implantable centrifugal blood pump for long term circulatory support. In: ASAIO Journal. 1997 ; Vol. 43, No. 5.
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