An implantable centrifugal blood pump with a recirculating purge system (Cool-Seal System)

Kenji Yamazaki, Philip Litwak, Osamu Tagusari, Toshio Mori, Kunihisa Kono, Marina Kameneva, Mary Watach, Lisa Gordon, Masayuki Miyagishima, Jun Tomioka, Mitsuo Umezu, Eisuke Outa, James F. Antaki, Robert L. Kormos, Hitoshi Koyanagi, Bartley P. Griffith

    Research output: Contribution to journalArticle

    66 Citations (Scopus)

    Abstract

    A compact centrifugal blood pump has been developed as an implantable left ventricular assist system. The impeller diameter is 40 mm, and pump dimensions are 55 x 64 mm. This first prototype, fabricated from titanium alloy, resulted in a pump weight of 400 g including a brushless DC motor. The weight of a second prototype pump was reduced to 280 g. The entire blood contacting surface is coated with diamond like carbon (DLC) to improve blood compatibility. Flow rates of over 7 L/min against 100 mm Hg pressure at 2,500 rpm with 9 W total power consumption have been measured. A newly designed mechanical seal with a recirculating purge system (Cool-Seal) is used for the shaft seal. In this seal system, the seal temperature is kept under 40°C to prevent heat denaturation of blood proteins. Purge fluid also cools the pump motor coil and journal bearing. Purge fluid is continuously purified and sterilized by an ultrafiltration unit which is incorporated in the paracorporeal drive console. In vitro experiments with bovine blood demonstrated an acceptably low hemolysis rate (normalized index of hemolysis = 0.005 ± 0.002 g/100 L). In vivo experiments are currently ongoing using calves. Via left thoracotomy, left ventricular (LV) apex descending aorta bypass was performed utilizing an expanded polytetrafluoroethylene (ePTFE) vascular graft with the pump placed in the left thoracic cavity. In 2 in vivo experiments, the pump flow rate was maintained at 5-9 l. L/min, and pump power consumption remained stable at 9-10 W. All plasma free Hb levels were measured at less than 15 mg/dl. The seal system has demonstrated good seal capability with negligible purge fluid consumption (<0.5 ml/day). In both calves, the pumps demonstrated trouble free continuous function over 6 month (200 days and 222 days).

    Original languageEnglish
    Pages (from-to)466-474
    Number of pages9
    JournalArtificial Organs
    Volume22
    Issue number6
    DOIs
    Publication statusPublished - 1998

    Fingerprint

    Seals
    Blood
    Pumps
    Hemolysis
    Thoracic Cavity
    Weights and Measures
    Diamond
    Ultrafiltration
    Polytetrafluoroethylene
    Thoracotomy
    Titanium
    Thoracic Aorta
    Blood Vessels
    Blood Proteins
    Fluids
    Carbon
    Hot Temperature
    Electric power utilization
    Transplants
    Flow rate

    Keywords

    • Centrifugal blood pump
    • Left ventricular assist system.

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Yamazaki, K., Litwak, P., Tagusari, O., Mori, T., Kono, K., Kameneva, M., ... Griffith, B. P. (1998). An implantable centrifugal blood pump with a recirculating purge system (Cool-Seal System). Artificial Organs, 22(6), 466-474. https://doi.org/10.1046/j.1525-1594.1998.06156.x

    An implantable centrifugal blood pump with a recirculating purge system (Cool-Seal System). / Yamazaki, Kenji; Litwak, Philip; Tagusari, Osamu; Mori, Toshio; Kono, Kunihisa; Kameneva, Marina; Watach, Mary; Gordon, Lisa; Miyagishima, Masayuki; Tomioka, Jun; Umezu, Mitsuo; Outa, Eisuke; Antaki, James F.; Kormos, Robert L.; Koyanagi, Hitoshi; Griffith, Bartley P.

    In: Artificial Organs, Vol. 22, No. 6, 1998, p. 466-474.

    Research output: Contribution to journalArticle

    Yamazaki, K, Litwak, P, Tagusari, O, Mori, T, Kono, K, Kameneva, M, Watach, M, Gordon, L, Miyagishima, M, Tomioka, J, Umezu, M, Outa, E, Antaki, JF, Kormos, RL, Koyanagi, H & Griffith, BP 1998, 'An implantable centrifugal blood pump with a recirculating purge system (Cool-Seal System)', Artificial Organs, vol. 22, no. 6, pp. 466-474. https://doi.org/10.1046/j.1525-1594.1998.06156.x
    Yamazaki, Kenji ; Litwak, Philip ; Tagusari, Osamu ; Mori, Toshio ; Kono, Kunihisa ; Kameneva, Marina ; Watach, Mary ; Gordon, Lisa ; Miyagishima, Masayuki ; Tomioka, Jun ; Umezu, Mitsuo ; Outa, Eisuke ; Antaki, James F. ; Kormos, Robert L. ; Koyanagi, Hitoshi ; Griffith, Bartley P. / An implantable centrifugal blood pump with a recirculating purge system (Cool-Seal System). In: Artificial Organs. 1998 ; Vol. 22, No. 6. pp. 466-474.
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    AU - Mori, Toshio

    AU - Kono, Kunihisa

    AU - Kameneva, Marina

    AU - Watach, Mary

    AU - Gordon, Lisa

    AU - Miyagishima, Masayuki

    AU - Tomioka, Jun

    AU - Umezu, Mitsuo

    AU - Outa, Eisuke

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