An integrated diagnosis and therapeutic system using intra-operative 5-aminolevulinic-acid-induced fluorescence guided robotic laser ablation for precision neurosurgery

Hongen Liao, Masafumi Noguchi, Takashi Maruyama, Yoshihiro Muragaki, Etsuko Kobayashi, Hiroshi Iseki, Ichiro Sakuma

    Research output: Contribution to journalArticle

    41 Citations (Scopus)

    Abstract

    We have developed an integrated diagnosis and therapeutic system for precision malignant gliomas resection during neurosurgery. A combination of three-dimensional (3-D) magnetic resonance imaging (MRI) navigation and 5-aminolevulinic acid (5-ALA)-induced fluorescence based intra-operative tumor diagnosis technique has been incorporated into a robotic laser ablation neurosurgery system with an automatic focusing and robotic scanning mechanism. 5-ALA is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent protoporphyrins IX (PpIX) in malignant glioma. The PpIX tends to accumulate in pathological lesions, and emits red fluorescence when excited by blue light. This fluorescence is illuminated with laser excitation, enables intra-operative identification of the position of a tumor and provides guidance for resection with laser photocoagulation. The information provided by the MRI is enhanced by the intra-operative 5-ALA fluorescence data, and this enhanced information is integrated into a robotic laser ablation system. The accuracy of the fluorescent measurement of the tumor is improved using high-precision spectral analysis. The fluorescence assists in the detection of malignant brain tumors intra-operatively and improves their removal rate.

    Original languageEnglish
    Pages (from-to)754-766
    Number of pages13
    JournalMedical Image Analysis
    Volume16
    Issue number3
    DOIs
    Publication statusPublished - 2012 Apr 1

    Keywords

    • 5-Aminolevulinic-acid
    • Fluorescence
    • Integrated diagnosis and therapeutic system
    • Medical robotics
    • Neurosurgery

    ASJC Scopus subject areas

    • Radiological and Ultrasound Technology
    • Radiology Nuclear Medicine and imaging
    • Computer Vision and Pattern Recognition
    • Health Informatics
    • Computer Graphics and Computer-Aided Design

    Fingerprint Dive into the research topics of 'An integrated diagnosis and therapeutic system using intra-operative 5-aminolevulinic-acid-induced fluorescence guided robotic laser ablation for precision neurosurgery'. Together they form a unique fingerprint.

  • Cite this