An ultrathin poly(L-lactic acid) nanosheet as a burn wound dressing for protection against bacterial infection

Hiromi Miyazaki, Manabu Kinoshita, Akihiro Saito, Toshinori Fujie, Koki Kabata, Etsuko Hara, Satoshi Ono, Shinji Takeoka, Daizoh Saitoh

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Burn wounds are highly susceptible to bacterial infection due to impairment of the skin's integrity. Therefore, prevention of bacterial colonization/infection in the wound is crucial for the management of burns, including partial-thickness burn injuries. Although partial-thickness burn injuries still retain the potential for reepithelialization, the complication of wound infection severely impairs the reepithelialization even in such superficial burn injuries. We recently developed a biocompatible nanosheet consisting of poly(L-lactic acid) (PLLA). The PLLA nanosheets have many useful and advantageous biological properties for their application as a wound dressing, such as sufficient flexibility, transparency, and adhesiveness. We herein investigated the suitability of the PLLA nanosheets as a wound dressing for partial-thickness burn wounds in mice. The PLLA nanosheets tightly adhered to the wound without any adhesive agents. Although wound infection with Pseudomonas aeruginosa in the controls significantly impaired reepithelialization of burn wounds, dressing with the PLLA nanosheet markedly protected against bacterial wound infection, thereby improving wound healing in the mice receiving partial-thickness burn injuries. The PLLA nanosheet also showed a potent barrier ability for protecting against bacterial penetration in vitro. The ultrathin PLLA nanosheet may be applied as a protective dressing to reduce environmental contamination of bacteria in a partial-thickness burn wound.

Original languageEnglish
Pages (from-to)573-579
Number of pages7
JournalWound Repair and Regeneration
Volume20
Issue number4
DOIs
Publication statusPublished - 2012 Jul

Fingerprint

Bandages
Bacterial Infections
Wounds and Injuries
Wound Infection
poly(lactic acid)
Adhesiveness
Burns
Adhesives
Wound Healing
Pseudomonas aeruginosa
Bacteria

ASJC Scopus subject areas

  • Dermatology
  • Surgery

Cite this

An ultrathin poly(L-lactic acid) nanosheet as a burn wound dressing for protection against bacterial infection. / Miyazaki, Hiromi; Kinoshita, Manabu; Saito, Akihiro; Fujie, Toshinori; Kabata, Koki; Hara, Etsuko; Ono, Satoshi; Takeoka, Shinji; Saitoh, Daizoh.

In: Wound Repair and Regeneration, Vol. 20, No. 4, 07.2012, p. 573-579.

Research output: Contribution to journalArticle

Miyazaki, Hiromi ; Kinoshita, Manabu ; Saito, Akihiro ; Fujie, Toshinori ; Kabata, Koki ; Hara, Etsuko ; Ono, Satoshi ; Takeoka, Shinji ; Saitoh, Daizoh. / An ultrathin poly(L-lactic acid) nanosheet as a burn wound dressing for protection against bacterial infection. In: Wound Repair and Regeneration. 2012 ; Vol. 20, No. 4. pp. 573-579.
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