Analysis for Distinctive Activation Patterns of Pain and Itchy in the Human Brain Cortex Measured Using Near Infrared Spectroscopy (NIRS)

Chih Hung Lee, Takashi Sugiyama, Aiko Kataoka, Ayako Kudo, Fukue Fujino, Yu Wen Chen, Yuki Mitsuyama, Shinobu Nomura, Tohru Yoshioka

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    Pain and itch are closely related sensations, yet qualitatively quite distinct. Despite recent advances in brain imaging techniques, identifying the differences between pain and itch signals in the brain cortex is difficult due to continuous temporal and spatial changes in the signals. The high spatial resolution of positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) has substantially advanced research of pain and itch, but these are uncomfortable because of expensiveness, importability and the limited operation in the shielded room. Here, we used near infrared spectroscopy (NIRS), which has more conventional usability. NIRS can be used to visualize dynamic changes in oxygenated hemoglobin and deoxyhemoglobin concentrations in the capillary networks near activated neural circuits in real-time as well as fMRI. We observed distinct activation patterns in the frontal cortex for acute pain and histamine-induced itch. The prefrontal cortex exhibited a pain-related and itch-related activation pattern of blood flow in each subject. Although it looked as though that activation pattern for pain and itching was different in each subject, further cross correlation analysis of NIRS signals between each channels showed an overall agreement with regard to prefrontal area involvement. As a result, pain-related and itch-related blood flow responses (delayed responses in prefrontal area) were found to be clearly different between pain (τ = +18.7 sec) and itch (τ = +0.63 sec) stimulation. This is the first pilot study to demonstrate the temporal and spatial separation of a pain-induced blood flow and an itch-induced blood flow in human cortex during information processing.

    Original languageEnglish
    Article numbere75360
    JournalPLoS One
    Volume8
    Issue number10
    DOIs
    Publication statusPublished - 2013 Oct 3

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    Activation Analysis
    Near infrared spectroscopy
    Near-Infrared Spectroscopy
    near-infrared spectroscopy
    pain
    Brain
    cortex
    Blood
    Chemical activation
    brain
    Pain
    blood flow
    Positron emission tomography
    Histamine
    magnetic resonance imaging
    Hemoglobins
    Magnetic Resonance Imaging
    Imaging techniques
    Networks (circuits)
    positron-emission tomography

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Medicine(all)

    Cite this

    Analysis for Distinctive Activation Patterns of Pain and Itchy in the Human Brain Cortex Measured Using Near Infrared Spectroscopy (NIRS). / Lee, Chih Hung; Sugiyama, Takashi; Kataoka, Aiko; Kudo, Ayako; Fujino, Fukue; Chen, Yu Wen; Mitsuyama, Yuki; Nomura, Shinobu; Yoshioka, Tohru.

    In: PLoS One, Vol. 8, No. 10, e75360, 03.10.2013.

    Research output: Contribution to journalArticle

    Lee, Chih Hung ; Sugiyama, Takashi ; Kataoka, Aiko ; Kudo, Ayako ; Fujino, Fukue ; Chen, Yu Wen ; Mitsuyama, Yuki ; Nomura, Shinobu ; Yoshioka, Tohru. / Analysis for Distinctive Activation Patterns of Pain and Itchy in the Human Brain Cortex Measured Using Near Infrared Spectroscopy (NIRS). In: PLoS One. 2013 ; Vol. 8, No. 10.
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