Analysis of tissue-specific DNA methylation during development.

Jun Ohgane, Naka Hattori, Kunio Shiota

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The establishment of a cell identification method more accurate than the conventional morphological and cell-type-specific marker analyses has been desired. DNA methylation is related to the gene activity including gene-silencing and is a key mechanism of epigenetics underling cellular differentiaion and development in mammals. Recent studies indicated that there exist unique genomic DNA methylation profiles specific to the cell type. DNA methylation profiles a mechanism for memorizing the set of genes inherent in individual type of cells. In this chapter, we present the methods to analyze DNA methylation status for identifying cells or tissues.

Original languageEnglish
Pages (from-to)371-382
Number of pages12
JournalMethods in molecular biology (Clifton, N.J.)
Volume289
Publication statusPublished - 2005
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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