Anterograde and retrograde amnesia of place discrimination in retrosplenial cortex and hippocampal lesioned rats

Asahi Haijima, Yukio Ichitani

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Retrograde and anterograde amnesic effects of excitotoxic lesions of the rat retrosplenial cortex (RS) and hippocampus (HPC) were investigated. To test retrograde amnesia, rats were trained with two-arm place discrimination in a radial maze 4 wk and 1 d before surgery with a different arm pair, respectively. In the retention test 1 wk after surgery, both lesion groups showed temporally ungraded retrograde amnesia. To test anterograde amnesia, animals were trained after surgery to discriminate three arm pairs successively within a day, and then after interposition of 1- to 4-wk intervals, one of these pairs, respectively, was tested for retention. RS-lesioned rats could acquire these pairs of place discriminations rapidly but showed a retention interval-dependent impairment in the retention test. Conversely, HPC-lesioned rats took more sessions to acquire these pairs than did the control group, and their retention was ∼70% of correct performance regardless of retention interval. Results suggest that RS and HPC have different roles in spatial memory and that RS is important for remote memory process.

Original languageEnglish
Pages (from-to)477-482
Number of pages6
JournalLearning and Memory
Volume15
Issue number7
DOIs
Publication statusPublished - 2008 Jul 1
Externally publishedYes

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Anterograde Amnesia
Retrograde Amnesia
Hippocampus
Long-Term Memory
Discrimination (Psychology)
Retention (Psychology)
Control Groups

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Anterograde and retrograde amnesia of place discrimination in retrosplenial cortex and hippocampal lesioned rats. / Haijima, Asahi; Ichitani, Yukio.

In: Learning and Memory, Vol. 15, No. 7, 01.07.2008, p. 477-482.

Research output: Contribution to journalArticle

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