Anti-diabetic effects of chondroitin sulfate on normal and type 2 diabetic mice

Mihoko Moto, Naoko Takamizawa, Tetsuhei Shibuya, Asae Nakamura, Kaname Katsuraya, Kazuyasu Iwasaki, Katsuyuki Tanaka, Akihiko Murota

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We evaluated the inhibitory effects of CS with different molecular weights from 170,000 to 10,000 Da on a-glucosidase activity in vitro. Low-molecular-weight CS (<16,000 Da) showed a higher inhibition of a-glucosidase activity than high-molecular-weight CS. In addition, we examined the effects of a single administration of low-molecular-weight CS on postprandial blood glucose in ICR mice. Low-molecular-weight CS inhibited the elevation of postprandial blood glucose in mice loaded with sucrose or starch as the source of carbohydrates. Finally, we investigated the anti-diabetic effects of daily administration of low- molecular-weight CS using type 2 diabetes model KK-Ay mice. The elevation of fasting blood glucose was inhibited in the CS group. These results suggest that the administration of low-molecular-weight CS prevents the elevation in the postprandial blood glucose level by reducing the digestion of carbohydrates in the gastrointestinal tract, leading to reductions of hyperglycemia in KK-Ay mice.

Original languageEnglish
Pages (from-to)336-340
Number of pages5
JournalJournal of Functional Foods
Volume40
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

chondroitin sulfate
glycemic effect
Chondroitin Sulfates
Molecular Weight
molecular weight
mice
blood glucose
Blood Glucose
Glucosidases
glucosidases
Carbohydrates
carbohydrates
Inbred ICR Mouse
hyperglycemia
noninsulin-dependent diabetes mellitus
Hyperglycemia
Starch
Type 2 Diabetes Mellitus
gastrointestinal system
fasting

Keywords

  • a-Glucosidase
  • Anti-diabetic effect
  • Chondroitin sulfate
  • Low molecular weight
  • Postprandial blood glucose

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Anti-diabetic effects of chondroitin sulfate on normal and type 2 diabetic mice. / Moto, Mihoko; Takamizawa, Naoko; Shibuya, Tetsuhei; Nakamura, Asae; Katsuraya, Kaname; Iwasaki, Kazuyasu; Tanaka, Katsuyuki; Murota, Akihiko.

In: Journal of Functional Foods, Vol. 40, 01.01.2018, p. 336-340.

Research output: Contribution to journalArticle

Moto, M, Takamizawa, N, Shibuya, T, Nakamura, A, Katsuraya, K, Iwasaki, K, Tanaka, K & Murota, A 2018, 'Anti-diabetic effects of chondroitin sulfate on normal and type 2 diabetic mice', Journal of Functional Foods, vol. 40, pp. 336-340. https://doi.org/10.1016/j.jff.2017.11.019
Moto, Mihoko ; Takamizawa, Naoko ; Shibuya, Tetsuhei ; Nakamura, Asae ; Katsuraya, Kaname ; Iwasaki, Kazuyasu ; Tanaka, Katsuyuki ; Murota, Akihiko. / Anti-diabetic effects of chondroitin sulfate on normal and type 2 diabetic mice. In: Journal of Functional Foods. 2018 ; Vol. 40. pp. 336-340.
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