TY - JOUR
T1 - Anti-diabetic effects of chondroitin sulfate on normal and type 2 diabetic mice
AU - Moto, Mihoko
AU - Takamizawa, Naoko
AU - Shibuya, Tetsuhei
AU - Nakamura, Asae
AU - Katsuraya, Kaname
AU - Iwasaki, Kazuyasu
AU - Tanaka, Katsuyuki
AU - Murota, Akihiko
N1 - Publisher Copyright:
© 2017
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2018/1
Y1 - 2018/1
N2 - We evaluated the inhibitory effects of CS with different molecular weights from 170,000 to 10,000 Da on a-glucosidase activity in vitro. Low-molecular-weight CS (<16,000 Da) showed a higher inhibition of a-glucosidase activity than high-molecular-weight CS. In addition, we examined the effects of a single administration of low-molecular-weight CS on postprandial blood glucose in ICR mice. Low-molecular-weight CS inhibited the elevation of postprandial blood glucose in mice loaded with sucrose or starch as the source of carbohydrates. Finally, we investigated the anti-diabetic effects of daily administration of low- molecular-weight CS using type 2 diabetes model KK-Ay mice. The elevation of fasting blood glucose was inhibited in the CS group. These results suggest that the administration of low-molecular-weight CS prevents the elevation in the postprandial blood glucose level by reducing the digestion of carbohydrates in the gastrointestinal tract, leading to reductions of hyperglycemia in KK-Ay mice.
AB - We evaluated the inhibitory effects of CS with different molecular weights from 170,000 to 10,000 Da on a-glucosidase activity in vitro. Low-molecular-weight CS (<16,000 Da) showed a higher inhibition of a-glucosidase activity than high-molecular-weight CS. In addition, we examined the effects of a single administration of low-molecular-weight CS on postprandial blood glucose in ICR mice. Low-molecular-weight CS inhibited the elevation of postprandial blood glucose in mice loaded with sucrose or starch as the source of carbohydrates. Finally, we investigated the anti-diabetic effects of daily administration of low- molecular-weight CS using type 2 diabetes model KK-Ay mice. The elevation of fasting blood glucose was inhibited in the CS group. These results suggest that the administration of low-molecular-weight CS prevents the elevation in the postprandial blood glucose level by reducing the digestion of carbohydrates in the gastrointestinal tract, leading to reductions of hyperglycemia in KK-Ay mice.
KW - Anti-diabetic effect
KW - Chondroitin sulfate
KW - Low molecular weight
KW - Postprandial blood glucose
KW - a-Glucosidase
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U2 - 10.1016/j.jff.2017.11.019
DO - 10.1016/j.jff.2017.11.019
M3 - Article
AN - SCOPUS:85034635450
SN - 1756-4646
VL - 40
SP - 336
EP - 340
JO - Journal of Functional Foods
JF - Journal of Functional Foods
ER -
