Anti-hyperglycaemic effects of the Japanese red maple Acer pycnanthum and its constituents the ginnalins B and C

Atsushi Honma, Tomoyuki Koyama, Kazunaga Yazawa

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The anti-hyperglycaemic effects of the leaves of Acer pycnanthum K. Koch, and the purification and identification of the active compounds were investigated. Extracts of the leaves showed a potent inhibitory effect on the α-glucosidase in both in vivo and in vitro experiments. The fractionation of the crude extract gave two active compounds, ginnalin B (6-O-galloyl-1,5- anhydro-D-glucitol) and ginnalin C (2-O-galloyl-1,5-anhydro-D-glucitol), by spectroscopic analysis. This is the first report that A. pycnanthum and its constituents may be useful for the prevention or treatment of diabetes mellitus.

Original languageEnglish
Pages (from-to)176-180
Number of pages5
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume26
Issue number2
DOIs
Publication statusPublished - 2011 Apr
Externally publishedYes

Keywords

  • á-glucosidase inhibitory effect
  • Acer pycnanthum
  • diabetes mellitus
  • ginnalin B
  • ginnalin C

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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