Anti-inflammatory effects of seeds of the tropical fruit camu-camu (Myrciaria dubia)

Kazunaga Yazawa, Katsumi Suga, Atsushi Honma, Miyuki Shirosaki, Tomoyuki Koyama

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The methanolic extract of seeds of the tropical fruit camu-camu was screened for its anti-inflammatory activity in carrageenan-induced paw edema model mice. The extract significantly suppressed both the formation of edema in mice by oral administration and the release of nitric oxide from macrophage-derived RAW 264.7 cells in vitro. Based on the results of a spectroscopic analysis, the active compound was identified by in vivo bioassay-guided fractionation to be 3β -hydroxy-lup-20(29)-en-28-oic acid, betulinic acid, known as an anti-inflammatory triterpenoid. These findings suggest that camu-camu seed extract is a potentially useful material as a source of betulinic acid and as a functional food for prevention of immune-related diseases.

Original languageEnglish
Pages (from-to)104-107
Number of pages4
JournalJournal of Nutritional Science and Vitaminology
Volume57
Issue number1
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Fruit
Edema
Seeds
Anti-Inflammatory Agents
Functional Food
Carrageenan
Immune System Diseases
Biological Assay
Oral Administration
Nitric Oxide
Macrophages
Acids
betulinic acid
RAW 264.7 Cells
In Vitro Techniques

Keywords

  • Anti-inflammatory effects in mice
  • Betulinic acid
  • Seed of camu-camu fruit myrciaria dubia
  • Suppressive effect on nitric oxide release

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Anti-inflammatory effects of seeds of the tropical fruit camu-camu (Myrciaria dubia). / Yazawa, Kazunaga; Suga, Katsumi; Honma, Atsushi; Shirosaki, Miyuki; Koyama, Tomoyuki.

In: Journal of Nutritional Science and Vitaminology, Vol. 57, No. 1, 2011, p. 104-107.

Research output: Contribution to journalArticle

Yazawa, Kazunaga ; Suga, Katsumi ; Honma, Atsushi ; Shirosaki, Miyuki ; Koyama, Tomoyuki. / Anti-inflammatory effects of seeds of the tropical fruit camu-camu (Myrciaria dubia). In: Journal of Nutritional Science and Vitaminology. 2011 ; Vol. 57, No. 1. pp. 104-107.
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