Anti-interleukin-6 autoantibodies in rheumatic diseases: Increased frequency in the sera of patients with systemic sclerosis

Hiroyuki Takemura, Hiroshi Suzuki, Kazuyuki Yoshizaki, Atsushi Ogata, Takamichi Yuhara, Takao Akama, Kazuhide Yamane, Heihachiro Kashiwagi

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Abstract

Objective. To investigate the presence and the roles of anti-interleukin-6 (anti-IL-6) autoantibodies in rheumatic diseases, and to further elucidate clinical and pathophysiologic significance of anticytokine autoantibodies. Methods. Anti-IL-6 IgG autoantibodies were measured by the 125I-IL-6 binding activity of IgG, which was isolated from serum by protein A-Sepharose. Results. Nine of 52 sera (17.3%) from patients with systemic sclerosis (SSc) contained anti-IL-6 antibodies, whereas only 1.9% of sera from normal subjects and 0-5% of sera from patients with other rheumatic diseases were positive for the antibodies. Moreover, anti-IL-6 autoantibodies were found predominantly among patients with the limited form of SSc (42.9%), compared with those with the diffuse form (7.9%). Conclusion. Anti-IL-6 IgG autoantibodies were detected in patients with SSc, particularly those with the limited form of the disease, at a significantly increased frequency compared with normal subjects and patients with other rheumatic diseases. These results suggest that the development of anti-IL-6 autoantibodies and IL-6 may have a role in the pathophysiology of SSc.

Original languageEnglish
Pages (from-to)940-943
Number of pages4
JournalArthritis and Rheumatism
Volume35
Issue number8
Publication statusPublished - 1992 Aug
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Takemura, H., Suzuki, H., Yoshizaki, K., Ogata, A., Yuhara, T., Akama, T., Yamane, K., & Kashiwagi, H. (1992). Anti-interleukin-6 autoantibodies in rheumatic diseases: Increased frequency in the sera of patients with systemic sclerosis. Arthritis and Rheumatism, 35(8), 940-943.