Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306

Toru Kimura, Masato Iwatsuki, Yukihiro Asami, Aki Ishiyama, Rei Hokari, Kazuhiko Otoguro, Atsuko Matsumoto, Noriko Sato, Kazuro Shiomi, Yoko Takahashi, Satoshi Omura, Takuji Nakashima

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

A new antibiotic, designated sagamilactam, was isolated from the cultured broth of Actinomadura sp. K13-0306 by Diaion HP-20, silica gel and octadecylsilane column chromatography followed by purification by HPLC. The chemical structure of the new compound was elucidated by spectroscopic analyses, including NMR and MS. The structure of sagamilactam proved to be a new compound consisting of a polyunsaturated and polyoxygenated 34-membered macrocyclic lactam containing diene, triene and tetraene conjugated olefins and a decalin moiety. Sagamilactam showed antitrypanosomal activity with an IC 50 value of 0.25±0.11 μM.

Original languageEnglish
Pages (from-to)818-824
Number of pages7
JournalJournal of Antibiotics
Volume69
Issue number11
DOIs
Publication statusPublished - 2016 Nov 1
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Fingerprint

Dive into the research topics of 'Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306'. Together they form a unique fingerprint.

Cite this