Anti-tumorigenesis of hollow calcium-phosphate microsphere loaded with anti-angiogenic agent

M. Aizawa, T. Ohno, Nobuhiro Kanomata, K. Yano, M. Emoto

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    We have successfully synthesized hollow biphasic calcium-phosphate microspheres consisting of the β-tricalcium phosphate (β-Ca 3(PO4)2; β-TCP) and calcium-deficient hydroxyapatite (DAp) using an ultrasonic spray-pyrolysis technique. The resulting hollow biphasic microspheres have been applied as a carrier of a drug delivery system (DDS) for medical treatment of cancers. An anti-angiogenic agent, TNP-470 (Takeda), was used as one of drug models. We have performed biological evaluations in vitro and in vivo using the biodegradable calcium-phosphate microsphere loaded with TNP-470. The results of in vitro and in vivo testing indicate that the microspheres loaded with TNP-470 inhibit i) the proliferation of FU-MMT-3 cells as a tumor model and ii) the enlargement of tumor sizes as a model of nude mice injected with FU-MMT-3 cells. The biological evaluations demonstrate that the present microspheres loaded with TNP-470 have an excellent anti-tumorigenesis effect.

    Original languageEnglish
    Pages (from-to)1215-1218
    Number of pages4
    JournalKey Engineering Materials
    Volume361-363 II
    Publication statusPublished - 2008

    Fingerprint

    Calcium phosphate
    Microspheres
    Tumors
    Spray pyrolysis
    Durapatite
    Hydroxyapatite
    Calcium
    Phosphates
    Ultrasonics
    calcium phosphate
    O-(chloroacetylcarbamoyl)fumagillol
    Testing
    Pharmaceutical Preparations
    2-methylcyclopentadienyl manganese tricarbonyl

    Keywords

    • Anti-tumorigenesis
    • Calcium phosphate
    • Drug delivery system (DDS)
    • Microsphere
    • Ultrasonic spray-pyrolysis technique

    ASJC Scopus subject areas

    • Ceramics and Composites
    • Chemical Engineering (miscellaneous)

    Cite this

    Anti-tumorigenesis of hollow calcium-phosphate microsphere loaded with anti-angiogenic agent. / Aizawa, M.; Ohno, T.; Kanomata, Nobuhiro; Yano, K.; Emoto, M.

    In: Key Engineering Materials, Vol. 361-363 II, 2008, p. 1215-1218.

    Research output: Contribution to journalArticle

    Aizawa, M. ; Ohno, T. ; Kanomata, Nobuhiro ; Yano, K. ; Emoto, M. / Anti-tumorigenesis of hollow calcium-phosphate microsphere loaded with anti-angiogenic agent. In: Key Engineering Materials. 2008 ; Vol. 361-363 II. pp. 1215-1218.
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    AU - Emoto, M.

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