Antibiotic production by the marine photosynthetic bacterium Chromatium purpuratum NKPB 031704: localization of activity to the chromatophores

J. Grant Burgess; Hideaki Miyashita; Hiroaki Sudo; Tadashi Matsunaga

Antibiotic production by the marine photosynthetic bacterium Chromatium purpuratum NKPB 031704: localization of activity to the chromatophores

J. Grant Burgess, Hideaki Miyashita, Hiroaki Sudo, Tadashi Matsunaga

Research output: Contribution to journal › Article

Abstract

Over 200 strains of marine purple photosynthetic bacteria were isolated. Two strains showed antibiotic activity towards Saccharomyces cerevisiae and were tentatively identified as Chromatium purpuratum. Crude antibiotic, prepared by solvent extraction, showed a broad antimicrobial spectrum. The highest activity was found in the chromatophore fraction. Chromatographic separation of purified light harvesting complex from one strain, NKPB 031704, showed the presence of two separate pigmented compounds which were responsible for antimicrobial activity. Our findings reveal the unexpected ability of photosynthetic bacteria to produce broad spectrum antibiotics. In addition, this is the first example of intracellular localization of antibiotic activity in a marine bacterium.

Original language	English
Pages (from-to)	301-305
Number of pages	5
Journal	FEMS Microbiology Letters
Volume	84
Issue number	3
Publication status	Published - 1991 Dec 1
Externally published	Yes

Fingerprint

Keywords

Antibiotic
Chromatium
Chromatophore
Marine bacteria
Photosynthetic bacteria
Purple sulfur photosynthetic bacteria

ASJC Scopus subject areas

Microbiology
Molecular Biology
Genetics

Cite this

Burgess, J. G., Miyashita, H., Sudo, H., & Matsunaga, T. (1991). Antibiotic production by the marine photosynthetic bacterium Chromatium purpuratum NKPB 031704: localization of activity to the chromatophores. FEMS Microbiology Letters, 84(3), 301-305.

@article{07889f72921a49ab957f8b2373bfbef4,

title = "Antibiotic production by the marine photosynthetic bacterium Chromatium purpuratum NKPB 031704: localization of activity to the chromatophores",

abstract = "Over 200 strains of marine purple photosynthetic bacteria were isolated. Two strains showed antibiotic activity towards Saccharomyces cerevisiae and were tentatively identified as Chromatium purpuratum. Crude antibiotic, prepared by solvent extraction, showed a broad antimicrobial spectrum. The highest activity was found in the chromatophore fraction. Chromatographic separation of purified light harvesting complex from one strain, NKPB 031704, showed the presence of two separate pigmented compounds which were responsible for antimicrobial activity. Our findings reveal the unexpected ability of photosynthetic bacteria to produce broad spectrum antibiotics. In addition, this is the first example of intracellular localization of antibiotic activity in a marine bacterium.",

keywords = "Antibiotic, Chromatium, Chromatophore, Marine bacteria, Photosynthetic bacteria, Purple sulfur photosynthetic bacteria",

author = "Burgess, {J. Grant} and Hideaki Miyashita and Hiroaki Sudo and Tadashi Matsunaga",

year = "1991",

month = dec

day = "1",

language = "English",

volume = "84",

pages = "301--305",

journal = "FEMS Microbiology Letters",

issn = "0378-1097",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - Antibiotic production by the marine photosynthetic bacterium Chromatium purpuratum NKPB 031704

T2 - localization of activity to the chromatophores

AU - Burgess, J. Grant

AU - Miyashita, Hideaki

AU - Sudo, Hiroaki

AU - Matsunaga, Tadashi

PY - 1991/12/1

Y1 - 1991/12/1

N2 - Over 200 strains of marine purple photosynthetic bacteria were isolated. Two strains showed antibiotic activity towards Saccharomyces cerevisiae and were tentatively identified as Chromatium purpuratum. Crude antibiotic, prepared by solvent extraction, showed a broad antimicrobial spectrum. The highest activity was found in the chromatophore fraction. Chromatographic separation of purified light harvesting complex from one strain, NKPB 031704, showed the presence of two separate pigmented compounds which were responsible for antimicrobial activity. Our findings reveal the unexpected ability of photosynthetic bacteria to produce broad spectrum antibiotics. In addition, this is the first example of intracellular localization of antibiotic activity in a marine bacterium.

AB - Over 200 strains of marine purple photosynthetic bacteria were isolated. Two strains showed antibiotic activity towards Saccharomyces cerevisiae and were tentatively identified as Chromatium purpuratum. Crude antibiotic, prepared by solvent extraction, showed a broad antimicrobial spectrum. The highest activity was found in the chromatophore fraction. Chromatographic separation of purified light harvesting complex from one strain, NKPB 031704, showed the presence of two separate pigmented compounds which were responsible for antimicrobial activity. Our findings reveal the unexpected ability of photosynthetic bacteria to produce broad spectrum antibiotics. In addition, this is the first example of intracellular localization of antibiotic activity in a marine bacterium.

KW - Antibiotic

KW - Chromatium

KW - Chromatophore

KW - Marine bacteria

KW - Photosynthetic bacteria

KW - Purple sulfur photosynthetic bacteria

UR - http://www.scopus.com/inward/record.url?scp=0025998819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025998819&partnerID=8YFLogxK

M3 - Article

C2 - 1804763

AN - SCOPUS:0025998819

VL - 84

SP - 301

EP - 305

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

SN - 0378-1097

IS - 3

ER -

Antibiotic production by the marine photosynthetic bacterium Chromatium purpuratum NKPB 031704: localization of activity to the chromatophores

Abstract

Fingerprint

Keywords

ASJC Scopus subject areas

Cite this

Access to Document