Antihyperglycemic effects of Japanese maple Acer amoenum leaf extract and its constituent corilagin

Atsushi Honma, Tomoyuki Koyama, Kazunaga Yazawa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The antihyperglycemic effects of the leaves of Acer amoenum and purification and identification of an active compound were investigated. In screening experiments for α-glucosidase inhibitory activity, methanolic extracts of A. amoenum leaves showed potent inhibitory action. This extract showed antihyperglycemic effects in sucrose-loaded mice. Fractionation of the crude extract gave the active compound corilagin [β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose] by spectroscopic analysis. This is the first report about the possibility of novel utilization of the Japanese maple tree as a source of compounds for prevention or treatment of diabetes mellitus.

Original languageEnglish
Pages (from-to)507-512
Number of pages6
JournalJournal of Wood Science
Volume56
Issue number6
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Spectroscopic analysis
Sugar (sucrose)
Fractionation
Medical problems
Hypoglycemic Agents
Purification
Glucose
Screening
Glucosidases
Complex Mixtures
Sucrose
Experiments
corilagin

Keywords

  • α-Glucosidase inhibitory effect
  • Acer amoenum
  • Corilagin
  • Diabetes mellitus
  • Japanese maple

ASJC Scopus subject areas

  • Biomaterials

Cite this

Antihyperglycemic effects of Japanese maple Acer amoenum leaf extract and its constituent corilagin. / Honma, Atsushi; Koyama, Tomoyuki; Yazawa, Kazunaga.

In: Journal of Wood Science, Vol. 56, No. 6, 2010, p. 507-512.

Research output: Contribution to journalArticle

Honma, Atsushi ; Koyama, Tomoyuki ; Yazawa, Kazunaga. / Antihyperglycemic effects of Japanese maple Acer amoenum leaf extract and its constituent corilagin. In: Journal of Wood Science. 2010 ; Vol. 56, No. 6. pp. 507-512.
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