Antihyperglycemic effects of Japanese maple Acer amoenum leaf extract and its constituent corilagin

Atsushi Honma, Tomoyuki Koyama, Kazunaga Yazawa

Research output: Contribution to journalArticle

10 Citations (Scopus)


The antihyperglycemic effects of the leaves of Acer amoenum and purification and identification of an active compound were investigated. In screening experiments for α-glucosidase inhibitory activity, methanolic extracts of A. amoenum leaves showed potent inhibitory action. This extract showed antihyperglycemic effects in sucrose-loaded mice. Fractionation of the crude extract gave the active compound corilagin [β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose] by spectroscopic analysis. This is the first report about the possibility of novel utilization of the Japanese maple tree as a source of compounds for prevention or treatment of diabetes mellitus.

Original languageEnglish
Pages (from-to)507-512
Number of pages6
JournalJournal of Wood Science
Issue number6
Publication statusPublished - 2010
Externally publishedYes



  • α-Glucosidase inhibitory effect
  • Acer amoenum
  • Corilagin
  • Diabetes mellitus
  • Japanese maple

ASJC Scopus subject areas

  • Biomaterials

Cite this