Abstract
PURPOSE: We examined the levels of autoantibodies against prethrombin-1 and fragment-1 in pregnant women to determine the type of autoantibodies that were associated with severe preeclampsia or spontaneous abortion. SUBJECTS AND METHODS: We measured autoantibodies bound to prothrombin, prethrombin-1, and fragment-1 by using an enzyme-linked immunosorbent assay (ELISA) in 12 healthy nonpregnant women, 36 women with normal pregnancies, 28 pregnant women with severe preeclampsia, and 19 pregnant women who subsequently had spontaneous abortion. RESULTS: Plasma samples in 10 (36%) of the 28 women with severe preeclampsia and 11 (58%) of the 19 women with spontaneous abortion were positive for antiprothrombin antibodies as compared with 3 (9%) of the 36 women with normal pregancies. All 11 of the positive samples from women who had spontaneous abortions were positive for antiprethrombin-1 antibody, but only 1 was positive for antifragment-1 antibody. The mean (± SD) titer of antiprethrombin-1 antibodies in patients with spontaneous abortion (36 ± 9 U) was higher than that in women with normal pregnancies (10 ± 4 U; P <0.01). Antiprethrombin-1 antibody was detected in only 2 women with severe preeclampsia, whereas all 10 women with antiprethrombin antibodies were positive for antifragment-1 antibody. The antifragment-1 antibody titer in patients with severe preeclampsia (49 ± 15 U) was higher than in women with normal pregnancies (13 ± 6 U, P <0.01). CONCLUSIONS: There is a strong and specific association between various types of antiprothrombin antibodies with severe preeclampsia and spontaneous abortion.
| Original language | English |
|---|---|
| Pages (from-to) | 188-191 |
| Number of pages | 4 |
| Journal | American Journal of Medicine |
| Volume | 110 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2001 Feb 15 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Nursing(all)
Cite this
Antiprothrombin autoantibodies in severe preeclampsia and abortion. / Akimoto, Takayuki; Akama, Takao; Saitoh, Masahiro; Kono, Ichiro; Sumida, Takayuki.
In: American Journal of Medicine, Vol. 110, No. 3, 15.02.2001, p. 188-191.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antiprothrombin autoantibodies in severe preeclampsia and abortion
AU - Akimoto, Takayuki
AU - Akama, Takao
AU - Saitoh, Masahiro
AU - Kono, Ichiro
AU - Sumida, Takayuki
PY - 2001/2/15
Y1 - 2001/2/15
N2 - PURPOSE: We examined the levels of autoantibodies against prethrombin-1 and fragment-1 in pregnant women to determine the type of autoantibodies that were associated with severe preeclampsia or spontaneous abortion. SUBJECTS AND METHODS: We measured autoantibodies bound to prothrombin, prethrombin-1, and fragment-1 by using an enzyme-linked immunosorbent assay (ELISA) in 12 healthy nonpregnant women, 36 women with normal pregnancies, 28 pregnant women with severe preeclampsia, and 19 pregnant women who subsequently had spontaneous abortion. RESULTS: Plasma samples in 10 (36%) of the 28 women with severe preeclampsia and 11 (58%) of the 19 women with spontaneous abortion were positive for antiprothrombin antibodies as compared with 3 (9%) of the 36 women with normal pregancies. All 11 of the positive samples from women who had spontaneous abortions were positive for antiprethrombin-1 antibody, but only 1 was positive for antifragment-1 antibody. The mean (± SD) titer of antiprethrombin-1 antibodies in patients with spontaneous abortion (36 ± 9 U) was higher than that in women with normal pregnancies (10 ± 4 U; P <0.01). Antiprethrombin-1 antibody was detected in only 2 women with severe preeclampsia, whereas all 10 women with antiprethrombin antibodies were positive for antifragment-1 antibody. The antifragment-1 antibody titer in patients with severe preeclampsia (49 ± 15 U) was higher than in women with normal pregnancies (13 ± 6 U, P <0.01). CONCLUSIONS: There is a strong and specific association between various types of antiprothrombin antibodies with severe preeclampsia and spontaneous abortion.
AB - PURPOSE: We examined the levels of autoantibodies against prethrombin-1 and fragment-1 in pregnant women to determine the type of autoantibodies that were associated with severe preeclampsia or spontaneous abortion. SUBJECTS AND METHODS: We measured autoantibodies bound to prothrombin, prethrombin-1, and fragment-1 by using an enzyme-linked immunosorbent assay (ELISA) in 12 healthy nonpregnant women, 36 women with normal pregnancies, 28 pregnant women with severe preeclampsia, and 19 pregnant women who subsequently had spontaneous abortion. RESULTS: Plasma samples in 10 (36%) of the 28 women with severe preeclampsia and 11 (58%) of the 19 women with spontaneous abortion were positive for antiprothrombin antibodies as compared with 3 (9%) of the 36 women with normal pregancies. All 11 of the positive samples from women who had spontaneous abortions were positive for antiprethrombin-1 antibody, but only 1 was positive for antifragment-1 antibody. The mean (± SD) titer of antiprethrombin-1 antibodies in patients with spontaneous abortion (36 ± 9 U) was higher than that in women with normal pregnancies (10 ± 4 U; P <0.01). Antiprethrombin-1 antibody was detected in only 2 women with severe preeclampsia, whereas all 10 women with antiprethrombin antibodies were positive for antifragment-1 antibody. The antifragment-1 antibody titer in patients with severe preeclampsia (49 ± 15 U) was higher than in women with normal pregnancies (13 ± 6 U, P <0.01). CONCLUSIONS: There is a strong and specific association between various types of antiprothrombin antibodies with severe preeclampsia and spontaneous abortion.
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U2 - 10.1016/S0002-9343(00)00694-X
DO - 10.1016/S0002-9343(00)00694-X
M3 - Article
VL - 110
SP - 188
EP - 191
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 3
ER -