Abstract
A series of pentanthrene type heterocyclic compounds were synthesized and evaluated for anxiolytic activities by three kinds of behavioral pharmacological tests. Several compounds showed anxiolytic activities. In particular, s-triazolo[3,4-a]phthalazine (Tri-P) and 3-propyl derivatives of Tri-P(PTP) showed remarkable activities, although the activities were slightly lower than those of diazepam. The results suggested that Tri-P or PTP is a useful lead compound for the development of the antianxietic agents. The relationship between the structure and anxiolytic activity, and the inducing mechanism of the activity was discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 400-405 |
| Number of pages | 6 |
| Journal | Yakugaku Zasshi |
| Volume | 113 |
| Issue number | 5 |
| Publication status | Published - 1993 |
| Externally published | Yes |
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Keywords
- anxiolytic activity
- behavioral pharmacological test
- pentanthrene type heterocyclic compound
- s-triazolo[3,4-a]phthalazine
ASJC Scopus subject areas
- Molecular Medicine
Cite this
Anxiolytic activities of pentanthrene type heterocyclic compounds. / Imamura, T.; Noda, A.; Shibata, Shigenobu; Watanabe, S.; Noda, H.; Ono, Y.; Goto, S.; Inoue, Y.
In: Yakugaku Zasshi, Vol. 113, No. 5, 1993, p. 400-405.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anxiolytic activities of pentanthrene type heterocyclic compounds
AU - Imamura, T.
AU - Noda, A.
AU - Shibata, Shigenobu
AU - Watanabe, S.
AU - Noda, H.
AU - Ono, Y.
AU - Goto, S.
AU - Inoue, Y.
PY - 1993
Y1 - 1993
N2 - A series of pentanthrene type heterocyclic compounds were synthesized and evaluated for anxiolytic activities by three kinds of behavioral pharmacological tests. Several compounds showed anxiolytic activities. In particular, s-triazolo[3,4-a]phthalazine (Tri-P) and 3-propyl derivatives of Tri-P(PTP) showed remarkable activities, although the activities were slightly lower than those of diazepam. The results suggested that Tri-P or PTP is a useful lead compound for the development of the antianxietic agents. The relationship between the structure and anxiolytic activity, and the inducing mechanism of the activity was discussed.
AB - A series of pentanthrene type heterocyclic compounds were synthesized and evaluated for anxiolytic activities by three kinds of behavioral pharmacological tests. Several compounds showed anxiolytic activities. In particular, s-triazolo[3,4-a]phthalazine (Tri-P) and 3-propyl derivatives of Tri-P(PTP) showed remarkable activities, although the activities were slightly lower than those of diazepam. The results suggested that Tri-P or PTP is a useful lead compound for the development of the antianxietic agents. The relationship between the structure and anxiolytic activity, and the inducing mechanism of the activity was discussed.
KW - anxiolytic activity
KW - behavioral pharmacological test
KW - pentanthrene type heterocyclic compound
KW - s-triazolo[3,4-a]phthalazine
UR - http://www.scopus.com/inward/record.url?scp=0027302693&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027302693&partnerID=8YFLogxK
M3 - Article
C2 - 8101567
AN - SCOPUS:0027302693
VL - 113
SP - 400
EP - 405
JO - Yakugaku Zasshi
JF - Yakugaku Zasshi
SN - 0031-6903
IS - 5
ER -