Abstract
A series of pentanthrene type heterocyclic compounds were synthesized and evaluated for anxiolytic activities by three kinds of behavioral pharmacological tests. Several compounds showed anxiolytic activities. In particular, s-triazolo[3,4-a]phthalazine (Tri-P) and 3-propyl derivatives of Tri-P(PTP) showed remarkable activities, although the activities were slightly lower than those of diazepam. The results suggested that Tri-P or PTP is a useful lead compound for the development of the antianxietic agents. The relationship between the structure and anxiolytic activity, and the inducing mechanism of the activity was discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 400-405 |
| Number of pages | 6 |
| Journal | Yakugaku Zasshi |
| Volume | 113 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1993 Jan 1 |
| Externally published | Yes |
Keywords
- anxiolytic activity
- behavioral pharmacological test
- pentanthrene type heterocyclic compound
- s-triazolo[3,4-a]phthalazine
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
Fingerprint Dive into the research topics of 'Anxiolytic activities of pentanthrene type heterocyclic compounds'. Together they form a unique fingerprint.
Cite this
Imamura, T., Noda, A., Shibata, S., Watanabe, S., Noda, H., Ono, Y., Goto, S., & Inoue, Y. (1993). Anxiolytic activities of pentanthrene type heterocyclic compounds. Yakugaku Zasshi, 113(5), 400-405. https://doi.org/10.1248/yakushi1947.113.5_400