Application of a statistical mechanical model for protein folding to a three-dimensional lattice protein

Haruo Abe, Hiroshi Wako

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A statistical mechanical model for protein folding is applied to the three-dimensional lattice protein using a foldable amino acid sequence. The key to the model lies in the concept of its local structure, defined as a continuous region which takes the same local conformation as in the native conformation, and in the assumption of the absence of interactions between local structures. The partition function is precisely calculated for a given native conformation without any adjustable parameters. The model can well reproduce the equilibrium thermodynamic quantities obtained from the simulation.

Original languageEnglish
Pages (from-to)1143-1146
Number of pages4
JournalJournal of the Physical Society of Japan
Volume73
Issue number5
DOIs
Publication statusPublished - 2004 May

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folding
proteins
thermodynamic equilibrium
amino acids
partitions
simulation
interactions

Keywords

  • 3d lattice protein
  • Monte Carlo simulation
  • Protein folding
  • Structural transition

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Application of a statistical mechanical model for protein folding to a three-dimensional lattice protein. / Abe, Haruo; Wako, Hiroshi.

In: Journal of the Physical Society of Japan, Vol. 73, No. 5, 05.2004, p. 1143-1146.

Research output: Contribution to journalArticle

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