Application of cycloolefin polymer chip directly integrated with an electronanospray tip to electrophoretic separation and mass spectrometric detection

Fumihiko Kitagawa, Takafumi Suzuki, Hidetoshi Shinohara, Jun Mizuno, Shuichi Shoji, Koji Otsuka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports a fabrication of cycloolefin polymer (COP) chip directly integrated with an electrospray ionization (ESI) emitter tip for a microchip electrophoretic (MCE) separation and mass spectrometric (MS) detection on the basis of the hot embossing, low temperature direct bonding, micromachining techniques and direct metallization onto the COP surface. By applying the fabricated COP chip to the MCE-ESI-MS analysis, a successful separation and detection of caffeine and amino acids was attained without any mechanical pump, nebulizing gas and sheath liquid.

Original languageEnglish
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages1405-1407
Number of pages3
ISBN (Electronic)9780979806407
Publication statusPublished - 2007
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: 2007 Oct 72007 Oct 11

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
CountryFrance
CityParis
Period07/10/707/10/11

Keywords

  • Cycloolefin polymer
  • Electrospray ionization
  • Mass spectrometry
  • Microchip electrophoresis

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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