Application of dimethylsulphoxide(DMSO) / trifluoroacetic acid(TFA) oxidation to the synthesis of cystine-containing peptide

Akira Otaka, Takaki Koide, Atsuko Shide, Nobutaka Fujii

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

S-protected cysteine derivatives [Cys(Trt), Cys(MBzl), Cys(Dbs), Cys(Bzh)] as well as cysteine were converted to cystine by the action of DMSO / TFA; as examples, two model peptides, oxytocin and an α-human calcitonin gene-related peptide (α-hCGRP), were prepared by this reaction.

Original languageEnglish
Pages (from-to)1223-1226
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number9
DOIs
Publication statusPublished - 1991 Feb 25
Externally publishedYes

Fingerprint

Trifluoroacetic Acid
Cystine
Dimethyl Sulfoxide
Cysteine
Oxidation
Peptides
Calcitonin Gene-Related Peptide
Oxytocin
Derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Application of dimethylsulphoxide(DMSO) / trifluoroacetic acid(TFA) oxidation to the synthesis of cystine-containing peptide. / Otaka, Akira; Koide, Takaki; Shide, Atsuko; Fujii, Nobutaka.

In: Tetrahedron Letters, Vol. 32, No. 9, 25.02.1991, p. 1223-1226.

Research output: Contribution to journalArticle

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