Application of dimethylsulphoxide(DMSO) / trifluoroacetic acid(TFA) oxidation to the synthesis of cystine-containing peptide

Akira Otaka, Takaki Koide, Atsuko Shide, Nobutaka Fujii

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

S-protected cysteine derivatives [Cys(Trt), Cys(MBzl), Cys(Dbs), Cys(Bzh)] as well as cysteine were converted to cystine by the action of DMSO / TFA; as examples, two model peptides, oxytocin and an α-human calcitonin gene-related peptide (α-hCGRP), were prepared by this reaction.

Original languageEnglish
Pages (from-to)1223-1226
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number9
DOIs
Publication statusPublished - 1991 Feb 25
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Application of dimethylsulphoxide(DMSO) / trifluoroacetic acid(TFA) oxidation to the synthesis of cystine-containing peptide'. Together they form a unique fingerprint.

  • Cite this