Abstract
The application of hydroxyapatite-sol as a drug carrier is being developed. Hydroxyapatite-sol which is a suspension consisting of hydroxyapatite nano-crystals, was synthesized using an ultrasonic homogenizer. The size of the crystals was 40 × 15 × 10 nm3 on average and their specific surface area was 100 m2/g. An amount of a glycoside antibiotics adsorbed onto hydroxyapatite nano-crystals was measured. The drug adsorbed 0.2 mg per 1 mg of hydroxyapatite. The affect of the drug adsorbed onto the hydroxyapatite was investigated using cancer cells. The drug, adsorbed onto the hydroxyapatite nano-crystals, inhibited cancer cell growth.
| Original language | English |
|---|---|
| Pages (from-to) | 283-290 |
| Number of pages | 8 |
| Journal | Bio-Medical Materials and Engineering |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1994 Jan 1 |
Keywords
- Drug carrier
- Hydroxyapatite-sol
- Nano-crystals
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
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Cite this
Kano, S., Yamazaki, A., Otsuka, R., Ohgaki, M., Akao, M., & Aoki, H. (1994). Application of hydroxyapatite-sol as drug carrier. Bio-Medical Materials and Engineering, 4(4), 283-290. https://doi.org/10.3233/BME-1994-4404