Application of hydroxyapatite-sol as drug carrier

Seisuke Kano, Atsushi Yamazaki, Ryohei Otsuka, Masataka Ohgaki, Masaru Akao, Hideki Aoki

    Research output: Contribution to journal › Article

    42 Citations (Scopus)

    Abstract

    The application of hydroxyapatite-sol as a drug carrier is being developed. Hydroxyapatite-sol which is a suspension consisting of hydroxyapatite nano-crystals, was synthesized using an ultrasonic homogenizer. The size of the crystals was 40 × 15 × 10 nm3 on average and their specific surface area was 100 m2/g. An amount of a glycoside antibiotics adsorbed onto hydroxyapatite nano-crystals was measured. The drug adsorbed 0.2 mg per 1 mg of hydroxyapatite. The affect of the drug adsorbed onto the hydroxyapatite was investigated using cancer cells. The drug, adsorbed onto the hydroxyapatite nano-crystals, inhibited cancer cell growth.

    Original languageEnglish
    Pages (from-to)283-290
    Number of pages8
    JournalBiomedical Materials and Engineering
    Volume4
    Issue number4
    Publication statusPublished - 1994

    Fingerprint

    Drug Carriers
    Polymethyl Methacrylate
    Durapatite
    Sols
    Hydroxyapatite
    Crystals
    Pharmaceutical Preparations
    Glycosides
    Cell growth
    Antibiotics
    Ultrasonics
    Specific surface area
    Neoplasms
    Suspensions
    Cells
    Anti-Bacterial Agents
    Growth

    Keywords

    • drug carrier
    • hydroxyapatite-sol
    • nano-crystals

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Kano, S., Yamazaki, A., Otsuka, R., Ohgaki, M., Akao, M., & Aoki, H. (1994). Application of hydroxyapatite-sol as drug carrier. Biomedical Materials and Engineering, 4(4), 283-290.

    Application of hydroxyapatite-sol as drug carrier. / Kano, Seisuke; Yamazaki, Atsushi; Otsuka, Ryohei; Ohgaki, Masataka; Akao, Masaru; Aoki, Hideki.

    In: Biomedical Materials and Engineering, Vol. 4, No. 4, 1994, p. 283-290.

    Research output: Contribution to journal › Article

    Kano, S, Yamazaki, A, Otsuka, R, Ohgaki, M, Akao, M & Aoki, H 1994, 'Application of hydroxyapatite-sol as drug carrier', Biomedical Materials and Engineering, vol. 4, no. 4, pp. 283-290.
    Kano S, Yamazaki A, Otsuka R, Ohgaki M, Akao M, Aoki H. Application of hydroxyapatite-sol as drug carrier. Biomedical Materials and Engineering. 1994;4(4):283-290.
    Kano, Seisuke ; Yamazaki, Atsushi ; Otsuka, Ryohei ; Ohgaki, Masataka ; Akao, Masaru ; Aoki, Hideki. / Application of hydroxyapatite-sol as drug carrier. In: Biomedical Materials and Engineering. 1994 ; Vol. 4, No. 4. pp. 283-290.
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