TY - JOUR
T1 - Application of hydroxyapatite-sol as drug carrier
AU - Kano, Seisuke
AU - Yamazaki, Atsushi
AU - Otsuka, Ryohei
AU - Ohgaki, Masataka
AU - Akao, Masaru
AU - Aoki, Hideki
PY - 1994/1/1
Y1 - 1994/1/1
N2 - The application of hydroxyapatite-sol as a drug carrier is being developed. Hydroxyapatite-sol which is a suspension consisting of hydroxyapatite nano-crystals, was synthesized using an ultrasonic homogenizer. The size of the crystals was 40 × 15 × 10 nm3 on average and their specific surface area was 100 m2/g. An amount of a glycoside antibiotics adsorbed onto hydroxyapatite nano-crystals was measured. The drug adsorbed 0.2 mg per 1 mg of hydroxyapatite. The affect of the drug adsorbed onto the hydroxyapatite was investigated using cancer cells. The drug, adsorbed onto the hydroxyapatite nano-crystals, inhibited cancer cell growth.
AB - The application of hydroxyapatite-sol as a drug carrier is being developed. Hydroxyapatite-sol which is a suspension consisting of hydroxyapatite nano-crystals, was synthesized using an ultrasonic homogenizer. The size of the crystals was 40 × 15 × 10 nm3 on average and their specific surface area was 100 m2/g. An amount of a glycoside antibiotics adsorbed onto hydroxyapatite nano-crystals was measured. The drug adsorbed 0.2 mg per 1 mg of hydroxyapatite. The affect of the drug adsorbed onto the hydroxyapatite was investigated using cancer cells. The drug, adsorbed onto the hydroxyapatite nano-crystals, inhibited cancer cell growth.
KW - Drug carrier
KW - Hydroxyapatite-sol
KW - Nano-crystals
UR - http://www.scopus.com/inward/record.url?scp=0028310514&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028310514&partnerID=8YFLogxK
U2 - 10.3233/BME-1994-4404
DO - 10.3233/BME-1994-4404
M3 - Article
C2 - 7950876
AN - SCOPUS:0028310514
VL - 4
SP - 283
EP - 290
JO - Bio-Medical Materials and Engineering
JF - Bio-Medical Materials and Engineering
SN - 0959-2989
IS - 4
ER -