Application of hydroxyapatite-sol as drug carrier

Seisuke Kano; Atsushi Yamazaki; Ryohei Otsuka; Masataka Ohgaki; Masaru Akao; Hideki Aoki

doi:10.3233/BME-1994-4404

Application of hydroxyapatite-sol as drug carrier

Seisuke Kano, Atsushi Yamazaki, Ryohei Otsuka, Masataka Ohgaki, Masaru Akao, Hideki Aoki

School of Creative Science and Engineering

Research output: Contribution to journal › Article

42 Citations (Scopus)

Abstract

The application of hydroxyapatite-sol as a drug carrier is being developed. Hydroxyapatite-sol which is a suspension consisting of hydroxyapatite nano-crystals, was synthesized using an ultrasonic homogenizer. The size of the crystals was 40 × 15 × 10 nm³ on average and their specific surface area was 100 m²/g. An amount of a glycoside antibiotics adsorbed onto hydroxyapatite nano-crystals was measured. The drug adsorbed 0.2 mg per 1 mg of hydroxyapatite. The affect of the drug adsorbed onto the hydroxyapatite was investigated using cancer cells. The drug, adsorbed onto the hydroxyapatite nano-crystals, inhibited cancer cell growth.

Original language	English
Pages (from-to)	283-290
Number of pages	8
Journal	Bio-Medical Materials and Engineering
Volume	4
Issue number	4
DOIs	https://doi.org/10.3233/BME-1994-4404
Publication status	Published - 1994 Jan 1

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Keywords

Drug carrier
Hydroxyapatite-sol
Nano-crystals

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

Cite this

Kano, S., Yamazaki, A., Otsuka, R., Ohgaki, M., Akao, M., & Aoki, H. (1994). Application of hydroxyapatite-sol as drug carrier. Bio-Medical Materials and Engineering, 4(4), 283-290. https://doi.org/10.3233/BME-1994-4404

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Access to Document

10.3233/BME-1994-4404