Application of infrared attenuated total reflection spectroscopy to in situ analysis of atheromatous plaques in aorta

Atsushi Nakamura, Takehiro Koga, Makoto Fujimaki, Yoshimichi Ohki, Takayuki Sota, Kristina Lipinska-Kalita, Tsuneyuki Nagae, Shin Ishimaru, Katsuo Aizawa

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Abstract

Ex vivo infrared attenuated total reflection (ATR) spectroscopic studies have been carried out to observe the accumulation of cholesterol ester in atheromatous plaques. It has been found that ATR spectra can be successfully obtained from the intima side of aorta and give the same information as the transmission spectra. This means, the ATR spectra include information about the chemical composition of atheromatous plaques together with the degree of eventual lesions. We have demonstrated that ATR microspectroscopic measurements can give images of atheromatous plaques distribution and enable in situ observation of the relative amount of accumulated cholesterol ester. The results clearly indicate that the ATR spectroscopy enables spectroscopic diagnoses in vivo as well as in vitro.

Original languageEnglish
JournalJapanese Journal of Applied Physics, Part 2: Letters
Volume39
Issue number6 A
Publication statusPublished - 2000

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aorta
Spectroscopy
Infrared radiation
spectroscopy
Cholesterol
cholesterol
esters
Esters
lesions
chemical composition
Chemical analysis

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Application of infrared attenuated total reflection spectroscopy to in situ analysis of atheromatous plaques in aorta. / Nakamura, Atsushi; Koga, Takehiro; Fujimaki, Makoto; Ohki, Yoshimichi; Sota, Takayuki; Lipinska-Kalita, Kristina; Nagae, Tsuneyuki; Ishimaru, Shin; Aizawa, Katsuo.

In: Japanese Journal of Applied Physics, Part 2: Letters, Vol. 39, No. 6 A, 2000.

Research output: Contribution to journalArticle

Nakamura, Atsushi ; Koga, Takehiro ; Fujimaki, Makoto ; Ohki, Yoshimichi ; Sota, Takayuki ; Lipinska-Kalita, Kristina ; Nagae, Tsuneyuki ; Ishimaru, Shin ; Aizawa, Katsuo. / Application of infrared attenuated total reflection spectroscopy to in situ analysis of atheromatous plaques in aorta. In: Japanese Journal of Applied Physics, Part 2: Letters. 2000 ; Vol. 39, No. 6 A.
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AU - Koga, Takehiro

AU - Fujimaki, Makoto

AU - Ohki, Yoshimichi

AU - Sota, Takayuki

AU - Lipinska-Kalita, Kristina

AU - Nagae, Tsuneyuki

AU - Ishimaru, Shin

AU - Aizawa, Katsuo

PY - 2000

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