Application of poly-l-lactic acid nanosheet as a material for wound dressing

Shimpo Aoki, Manabu Kinoshita, Hiromi Miyazaki, Akihiro Saito, Toshinori Fujie, Keiichi Iwaya, Shinji Takeoka, Daizoh Saitoh

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The authors evaluated the efficacy of an ultrathin nanosheet consisting of poly-L-lactic acid (75 nm thick) as a wound dressing material. A full-thickness skin defect was made on the backs of mice and overlapped with or without the poly-L-lactic acid nanosheet. Wound healing was more rapidly improved by overlapping with the nanosheet, especially in the early healing period (at 4 to 6 days). The remaining wound area in the treatment group was significantly smaller at 4 days than in the control group. Histologically, a clear layer was observed over the granulation layer by the nanosheet therapy at 4 days. Thus, overlapping therapy with the poly-L-lactic acid nanosheet accelerated wound healing and formed a clear layer just above the granulation tissue. The poly-L-lactic acid nanosheet may have potential as a novel wound dressing to promote wound healing.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalPlastic and Reconstructive Surgery
Volume131
Issue number2
DOIs
Publication statusPublished - 2013 Feb

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Bandages
Wound Healing
Wounds and Injuries
Granulation Tissue
Control Groups
Skin
poly(lactic acid)
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Aoki, S., Kinoshita, M., Miyazaki, H., Saito, A., Fujie, T., Iwaya, K., ... Saitoh, D. (2013). Application of poly-l-lactic acid nanosheet as a material for wound dressing. Plastic and Reconstructive Surgery, 131(2), 236-240. https://doi.org/10.1097/PRS.0b013e3182789c79

Application of poly-l-lactic acid nanosheet as a material for wound dressing. / Aoki, Shimpo; Kinoshita, Manabu; Miyazaki, Hiromi; Saito, Akihiro; Fujie, Toshinori; Iwaya, Keiichi; Takeoka, Shinji; Saitoh, Daizoh.

In: Plastic and Reconstructive Surgery, Vol. 131, No. 2, 02.2013, p. 236-240.

Research output: Contribution to journalArticle

Aoki, S, Kinoshita, M, Miyazaki, H, Saito, A, Fujie, T, Iwaya, K, Takeoka, S & Saitoh, D 2013, 'Application of poly-l-lactic acid nanosheet as a material for wound dressing', Plastic and Reconstructive Surgery, vol. 131, no. 2, pp. 236-240. https://doi.org/10.1097/PRS.0b013e3182789c79
Aoki, Shimpo ; Kinoshita, Manabu ; Miyazaki, Hiromi ; Saito, Akihiro ; Fujie, Toshinori ; Iwaya, Keiichi ; Takeoka, Shinji ; Saitoh, Daizoh. / Application of poly-l-lactic acid nanosheet as a material for wound dressing. In: Plastic and Reconstructive Surgery. 2013 ; Vol. 131, No. 2. pp. 236-240.
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