Application of poly-l-lactic acid nanosheet as a material for wound dressing

Shimpo Aoki, Manabu Kinoshita, Hiromi Miyazaki, Akihiro Saito, Toshinori Fujie, Keiichi Iwaya, Shinji Takeoka, Daizoh Saitoh

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Abstract

The authors evaluated the efficacy of an ultrathin nanosheet consisting of poly-L-lactic acid (75 nm thick) as a wound dressing material. A full-thickness skin defect was made on the backs of mice and overlapped with or without the poly-L-lactic acid nanosheet. Wound healing was more rapidly improved by overlapping with the nanosheet, especially in the early healing period (at 4 to 6 days). The remaining wound area in the treatment group was significantly smaller at 4 days than in the control group. Histologically, a clear layer was observed over the granulation layer by the nanosheet therapy at 4 days. Thus, overlapping therapy with the poly-L-lactic acid nanosheet accelerated wound healing and formed a clear layer just above the granulation tissue. The poly-L-lactic acid nanosheet may have potential as a novel wound dressing to promote wound healing.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalPlastic and Reconstructive Surgery
Volume131
Issue number2
DOIs
Publication statusPublished - 2013 Feb 1

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ASJC Scopus subject areas

  • Surgery

Cite this

Aoki, S., Kinoshita, M., Miyazaki, H., Saito, A., Fujie, T., Iwaya, K., Takeoka, S., & Saitoh, D. (2013). Application of poly-l-lactic acid nanosheet as a material for wound dressing. Plastic and Reconstructive Surgery, 131(2), 236-240. https://doi.org/10.1097/PRS.0b013e3182789c79