Aqueous elution control in wettability modulated microchannels grafted with thermoresponsive polymers

Naokazu Idota, Akihiko Kikuchi, Jun Kobayashi, Kiyotaka Sakai, Teruo Okano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Temperature-dependent aqueous wettability of poly(N-isopropylacrylamide) (PIPAAm)-grafted surfaces was regulated by grafted polymer layer thickness and basic hydrophobicities of the polymer-grafted surfaces. Thermoresponsive surfaces with controlled polymer layer thickness were prepared by surface-initiated atom transfer radical polymerization (ATRP). Static contact angles for both surfaces were drastically changed in response to temperature alteration. Hydrophilic property of PIPAAm-grafted surfaces depends on polymer layer thickness at low temperature range. More hydrophobic surface properties were observed for poly (n-butyl methacrylate) (PBMA)-b-PIPAAm-grafted surfaces than IPAAm homopolymer-grafted surfaces above PIPAAm's transition. The changes of static contact angles for both surfaces were drastically changed in response to temperature alteration temperature. Well-defined thermoresponsive microchannels were then fabricated for elution control of steroids through the modulation of surface characteristics by temperature. Using PIPAAm-grafted hollow capillaries, baseline separation of steroids was successfully achieved within 10min by changing only temperature. Furthermore, the hydrophobic testosterone showed stronger hydrophobic interaction on more hydrophobized PBMA-b-PIPAAm-grafted surfaces above the PIPAAm's transition temperature.

Original languageEnglish
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages1264-1266
Number of pages3
Volume1
ISBN (Print)0974361119, 9780974361116
Publication statusPublished - 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA
Duration: 2005 Oct 92005 Oct 13

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CityBoston, MA
Period05/10/905/10/13

Keywords

  • Atom transfer radical polymerization
  • Block copolymer
  • Hydrophobic interaction
  • Thermoresponsive polymer

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Idota, N., Kikuchi, A., Kobayashi, J., Sakai, K., & Okano, T. (2005). Aqueous elution control in wettability modulated microchannels grafted with thermoresponsive polymers. In Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (Vol. 1, pp. 1264-1266). Transducer Research Foundation.