Are the neuroprotective effects of estradiol and physical exercise comparable during ageing in female rats?

Krisztina Marosi, Klára Felszeghy, Raj D. Mehra, Zsolt Radak, Csaba Nyakas

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Ageing of the brain is accompanied by variable degrees of cognitive decline. Estrogens have profound effects on brain ageing by exerting neurotrophic and neuroprotective types of action. Furthermore, exercise has also been claimed to play a role in the non-pharmacological prevention of psycho-neuronal decline with ageing. In the present study the question was asked whether chronic physical exercise might substitute the action of estrogens in aged rats. We compared the effects of 17β-estradiol (E2) treatment and long-term moderate physical exercise in ageing (15 months, early stage of ageing) and old (27 months) female rats, on cognitive functions and the relevant intracellular molecular signaling pathways in the hippocampus. Results showed that both treatments improved attention and memory functions of the 15 months old rats. Like E2, physical training enhanced the level of brain derived nerve growth factor and the activation of PKA/Akt/CREB and MAPK/CREB pathways. The treatments also enhanced the levels of synaptic molecules synaptophysin and synapsin I, which could explain the improved cognitive functions. In the 27 months old rats the behavioral and molecular effects of E2 were indistinguishable from those found in the 15 months old animals but the effects of physical exercise in most of the measures proved to be practically ineffective. It is concluded that the effectiveness of regular and moderate intensity physical exercise is age-dependent while the action of E2 treatment is comparable between the ageing and old female rats on maintaining cognition and its underlying molecular mechanisms.

Original languageEnglish
Pages (from-to)413-427
Number of pages15
JournalBiogerontology
Volume13
Issue number4
DOIs
Publication statusPublished - 2012 Aug 1
Externally publishedYes

Fingerprint

Neuroprotective Agents
Estradiol
Exercise
Cognition
Brain
Estrogens
Synapsins
Synaptophysin
Nerve Growth Factor
Therapeutics
Hippocampus

Keywords

  • Ageing
  • Cognition
  • Estradiol
  • Exercise
  • Hippocampus

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology
  • Ageing

Cite this

Are the neuroprotective effects of estradiol and physical exercise comparable during ageing in female rats? / Marosi, Krisztina; Felszeghy, Klára; Mehra, Raj D.; Radak, Zsolt; Nyakas, Csaba.

In: Biogerontology, Vol. 13, No. 4, 01.08.2012, p. 413-427.

Research output: Contribution to journalArticle

Marosi, Krisztina ; Felszeghy, Klára ; Mehra, Raj D. ; Radak, Zsolt ; Nyakas, Csaba. / Are the neuroprotective effects of estradiol and physical exercise comparable during ageing in female rats?. In: Biogerontology. 2012 ; Vol. 13, No. 4. pp. 413-427.
@article{0cb9f2f7adc74c9096e65832f90ac33a,
title = "Are the neuroprotective effects of estradiol and physical exercise comparable during ageing in female rats?",
abstract = "Ageing of the brain is accompanied by variable degrees of cognitive decline. Estrogens have profound effects on brain ageing by exerting neurotrophic and neuroprotective types of action. Furthermore, exercise has also been claimed to play a role in the non-pharmacological prevention of psycho-neuronal decline with ageing. In the present study the question was asked whether chronic physical exercise might substitute the action of estrogens in aged rats. We compared the effects of 17β-estradiol (E2) treatment and long-term moderate physical exercise in ageing (15 months, early stage of ageing) and old (27 months) female rats, on cognitive functions and the relevant intracellular molecular signaling pathways in the hippocampus. Results showed that both treatments improved attention and memory functions of the 15 months old rats. Like E2, physical training enhanced the level of brain derived nerve growth factor and the activation of PKA/Akt/CREB and MAPK/CREB pathways. The treatments also enhanced the levels of synaptic molecules synaptophysin and synapsin I, which could explain the improved cognitive functions. In the 27 months old rats the behavioral and molecular effects of E2 were indistinguishable from those found in the 15 months old animals but the effects of physical exercise in most of the measures proved to be practically ineffective. It is concluded that the effectiveness of regular and moderate intensity physical exercise is age-dependent while the action of E2 treatment is comparable between the ageing and old female rats on maintaining cognition and its underlying molecular mechanisms.",
keywords = "Ageing, Cognition, Estradiol, Exercise, Hippocampus",
author = "Krisztina Marosi and Kl{\'a}ra Felszeghy and Mehra, {Raj D.} and Zsolt Radak and Csaba Nyakas",
year = "2012",
month = "8",
day = "1",
doi = "10.1007/s10522-012-9386-3",
language = "English",
volume = "13",
pages = "413--427",
journal = "Biogerontology",
issn = "1389-5729",
publisher = "Springer Netherlands",
number = "4",

}

TY - JOUR

T1 - Are the neuroprotective effects of estradiol and physical exercise comparable during ageing in female rats?

AU - Marosi, Krisztina

AU - Felszeghy, Klára

AU - Mehra, Raj D.

AU - Radak, Zsolt

AU - Nyakas, Csaba

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Ageing of the brain is accompanied by variable degrees of cognitive decline. Estrogens have profound effects on brain ageing by exerting neurotrophic and neuroprotective types of action. Furthermore, exercise has also been claimed to play a role in the non-pharmacological prevention of psycho-neuronal decline with ageing. In the present study the question was asked whether chronic physical exercise might substitute the action of estrogens in aged rats. We compared the effects of 17β-estradiol (E2) treatment and long-term moderate physical exercise in ageing (15 months, early stage of ageing) and old (27 months) female rats, on cognitive functions and the relevant intracellular molecular signaling pathways in the hippocampus. Results showed that both treatments improved attention and memory functions of the 15 months old rats. Like E2, physical training enhanced the level of brain derived nerve growth factor and the activation of PKA/Akt/CREB and MAPK/CREB pathways. The treatments also enhanced the levels of synaptic molecules synaptophysin and synapsin I, which could explain the improved cognitive functions. In the 27 months old rats the behavioral and molecular effects of E2 were indistinguishable from those found in the 15 months old animals but the effects of physical exercise in most of the measures proved to be practically ineffective. It is concluded that the effectiveness of regular and moderate intensity physical exercise is age-dependent while the action of E2 treatment is comparable between the ageing and old female rats on maintaining cognition and its underlying molecular mechanisms.

AB - Ageing of the brain is accompanied by variable degrees of cognitive decline. Estrogens have profound effects on brain ageing by exerting neurotrophic and neuroprotective types of action. Furthermore, exercise has also been claimed to play a role in the non-pharmacological prevention of psycho-neuronal decline with ageing. In the present study the question was asked whether chronic physical exercise might substitute the action of estrogens in aged rats. We compared the effects of 17β-estradiol (E2) treatment and long-term moderate physical exercise in ageing (15 months, early stage of ageing) and old (27 months) female rats, on cognitive functions and the relevant intracellular molecular signaling pathways in the hippocampus. Results showed that both treatments improved attention and memory functions of the 15 months old rats. Like E2, physical training enhanced the level of brain derived nerve growth factor and the activation of PKA/Akt/CREB and MAPK/CREB pathways. The treatments also enhanced the levels of synaptic molecules synaptophysin and synapsin I, which could explain the improved cognitive functions. In the 27 months old rats the behavioral and molecular effects of E2 were indistinguishable from those found in the 15 months old animals but the effects of physical exercise in most of the measures proved to be practically ineffective. It is concluded that the effectiveness of regular and moderate intensity physical exercise is age-dependent while the action of E2 treatment is comparable between the ageing and old female rats on maintaining cognition and its underlying molecular mechanisms.

KW - Ageing

KW - Cognition

KW - Estradiol

KW - Exercise

KW - Hippocampus

UR - http://www.scopus.com/inward/record.url?scp=84865375227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865375227&partnerID=8YFLogxK

U2 - 10.1007/s10522-012-9386-3

DO - 10.1007/s10522-012-9386-3

M3 - Article

C2 - 22722983

AN - SCOPUS:84865375227

VL - 13

SP - 413

EP - 427

JO - Biogerontology

JF - Biogerontology

SN - 1389-5729

IS - 4

ER -