Aromatic C-H coupling with hindered arylboronic acids by Pd/Fe dual catalysts

Kazuya Yamaguchi, Hiroki Kondo, Junichiro Yamaguchi, Kenichiro Itami

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78 Citations (Scopus)

Abstract

An aerobic oxidative coupling of arenes/alkenes with arylboronic acids (C-H/C-B coupling) using catalytic Pd(ii)-sulfoxide-oxazoline (sox) ligand and iron-phthalocyanine (FePc) has been developed. This dual catalyst system enables the synthesis of sterically hindered heterobiaryls and styrene derivatives under air without stoichiometric co-oxidants. Additionally, this chemistry demonstrated an advance toward an enantioselective biaryl coupling through C-H functionalization.

Original languageEnglish
Pages (from-to)3753-3757
Number of pages5
JournalChemical Science
Volume4
Issue number9
DOIs
Publication statusPublished - 2013 Sep
Externally publishedYes

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ASJC Scopus subject areas

  • Chemistry(all)

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