Artificial collagen gels via self-assembly of de novo designed peptides.

Chisato M. Yamazaki, Shinichi Asada, Kouki Kitagawa, Takaki Koide

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56 Citations (Scopus)

Abstract

Development of artificial collagens to replace the animal-derived collagens presents a challenge in the formation of safer and functional biomaterials. We report here the development of collagen-like gels by means of the self-assembly of chemically synthesized peptides. The peptides are disulfide-linked trimers of collagenous Gly-X-Y triplet repeats with self-complementary shapes. Upon cooling the peptide solutions, hydrogels of peptide supramolecules are formed by spontaneous intermolecular triple helix formation. The thermal gel-sol transition appeared to be reversible, and the transition temperatures were found to be tunable by the design of the peptides. Our systems for the formation of artificial collagen-like gels will offer possibilities for novel types of biomaterials.

Original languageEnglish
Pages (from-to)816-823
Number of pages8
JournalBiopolymers
Volume90
Issue number6
DOIs
Publication statusPublished - 2008

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry

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