As sociations between the serum 25(OH)D concentration and lipid profiles in Japanese men

Xiaomin Sun, Zhen Bo Cao, Kumpei Tanisawa, Tomoko Ito, Satomi Oshima, Yoshiko Ishimi, Izumi Tabata, Mitsuru Higuchi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aim: Low circulating 25-hydroxyvitamin D [25(OH)D] concentration has been linked to a high prevalence of cardiovascular disease. One explanation for this phenomenon is that there is an association between the serum 25(OH)D level and lipid profiles. However, studies examining this relationship are limited and have yielded inconsistent results. We thus aimed to evaluate the association between the serum 25(OH)D concentration and lipid profiles in Japanese men taking into consideration confounding factors, including the visceral fat area (VFA. and cardiorespiratory fitness. Methods: A total of 136 men (age range: 20-79 years. participated in our study. Fasting blood samples were analyzed to determine the 25(OH)D, oxidized low-density lipoprotein (oxLDL), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), apolipoprotein (Apo)A-1 and ApoB levels. The VFA was evaluated on magnetic resonance imaging (MRI), and cardiorespiratory fitness was assessed by measuring the peak oxygen uptake (V4O2 peak). Results: The median 25(OH)D concentration was 35.6 nmol/L, and the prevalence of 25(OH)D deficiency was 78.7%. A multiple linear regression analysis revealed that the serum 25(OH)D concentration was inversely related to the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values, even after adjusting for age, season, smoking status, alcohol consumption, medication use, vitamin D intake, calcium intake, VFA and cardiorespiratory fitness. Conclusions: Serum 25(OH)D level is inversely correlated with the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values in Japanese men, independent of the VFA and cardiorespiratory fitness.

Original languageEnglish
Pages (from-to)355-362
Number of pages8
JournalJournal of Atherosclerosis and Thrombosis
Volume22
Issue number4
DOIs
Publication statusPublished - 2015

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Apolipoproteins B
Apolipoprotein A-I
Lipids
LDL Cholesterol
HDL Cholesterol
Serum
Triglycerides
Intra-Abdominal Fat
Magnetic resonance
Linear regression
Vitamin D
Regression analysis
Alcohol Drinking
Linear Models
Fasting
Blood
Cardiovascular Diseases
Smoking
Fats
Regression Analysis

Keywords

  • Cardiorespiratory fitness
  • Lipids
  • Visceral fat
  • Vitamin D

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Biochemistry, medical

Cite this

As sociations between the serum 25(OH)D concentration and lipid profiles in Japanese men. / Sun, Xiaomin; Cao, Zhen Bo; Tanisawa, Kumpei; Ito, Tomoko; Oshima, Satomi; Ishimi, Yoshiko; Tabata, Izumi; Higuchi, Mitsuru.

In: Journal of Atherosclerosis and Thrombosis, Vol. 22, No. 4, 2015, p. 355-362.

Research output: Contribution to journalArticle

Sun, Xiaomin ; Cao, Zhen Bo ; Tanisawa, Kumpei ; Ito, Tomoko ; Oshima, Satomi ; Ishimi, Yoshiko ; Tabata, Izumi ; Higuchi, Mitsuru. / As sociations between the serum 25(OH)D concentration and lipid profiles in Japanese men. In: Journal of Atherosclerosis and Thrombosis. 2015 ; Vol. 22, No. 4. pp. 355-362.
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abstract = "Aim: Low circulating 25-hydroxyvitamin D [25(OH)D] concentration has been linked to a high prevalence of cardiovascular disease. One explanation for this phenomenon is that there is an association between the serum 25(OH)D level and lipid profiles. However, studies examining this relationship are limited and have yielded inconsistent results. We thus aimed to evaluate the association between the serum 25(OH)D concentration and lipid profiles in Japanese men taking into consideration confounding factors, including the visceral fat area (VFA. and cardiorespiratory fitness. Methods: A total of 136 men (age range: 20-79 years. participated in our study. Fasting blood samples were analyzed to determine the 25(OH)D, oxidized low-density lipoprotein (oxLDL), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), apolipoprotein (Apo)A-1 and ApoB levels. The VFA was evaluated on magnetic resonance imaging (MRI), and cardiorespiratory fitness was assessed by measuring the peak oxygen uptake (V4O2 peak). Results: The median 25(OH)D concentration was 35.6 nmol/L, and the prevalence of 25(OH)D deficiency was 78.7{\%}. A multiple linear regression analysis revealed that the serum 25(OH)D concentration was inversely related to the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values, even after adjusting for age, season, smoking status, alcohol consumption, medication use, vitamin D intake, calcium intake, VFA and cardiorespiratory fitness. Conclusions: Serum 25(OH)D level is inversely correlated with the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values in Japanese men, independent of the VFA and cardiorespiratory fitness.",
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T1 - As sociations between the serum 25(OH)D concentration and lipid profiles in Japanese men

AU - Sun, Xiaomin

AU - Cao, Zhen Bo

AU - Tanisawa, Kumpei

AU - Ito, Tomoko

AU - Oshima, Satomi

AU - Ishimi, Yoshiko

AU - Tabata, Izumi

AU - Higuchi, Mitsuru

PY - 2015

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N2 - Aim: Low circulating 25-hydroxyvitamin D [25(OH)D] concentration has been linked to a high prevalence of cardiovascular disease. One explanation for this phenomenon is that there is an association between the serum 25(OH)D level and lipid profiles. However, studies examining this relationship are limited and have yielded inconsistent results. We thus aimed to evaluate the association between the serum 25(OH)D concentration and lipid profiles in Japanese men taking into consideration confounding factors, including the visceral fat area (VFA. and cardiorespiratory fitness. Methods: A total of 136 men (age range: 20-79 years. participated in our study. Fasting blood samples were analyzed to determine the 25(OH)D, oxidized low-density lipoprotein (oxLDL), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), apolipoprotein (Apo)A-1 and ApoB levels. The VFA was evaluated on magnetic resonance imaging (MRI), and cardiorespiratory fitness was assessed by measuring the peak oxygen uptake (V4O2 peak). Results: The median 25(OH)D concentration was 35.6 nmol/L, and the prevalence of 25(OH)D deficiency was 78.7%. A multiple linear regression analysis revealed that the serum 25(OH)D concentration was inversely related to the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values, even after adjusting for age, season, smoking status, alcohol consumption, medication use, vitamin D intake, calcium intake, VFA and cardiorespiratory fitness. Conclusions: Serum 25(OH)D level is inversely correlated with the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values in Japanese men, independent of the VFA and cardiorespiratory fitness.

AB - Aim: Low circulating 25-hydroxyvitamin D [25(OH)D] concentration has been linked to a high prevalence of cardiovascular disease. One explanation for this phenomenon is that there is an association between the serum 25(OH)D level and lipid profiles. However, studies examining this relationship are limited and have yielded inconsistent results. We thus aimed to evaluate the association between the serum 25(OH)D concentration and lipid profiles in Japanese men taking into consideration confounding factors, including the visceral fat area (VFA. and cardiorespiratory fitness. Methods: A total of 136 men (age range: 20-79 years. participated in our study. Fasting blood samples were analyzed to determine the 25(OH)D, oxidized low-density lipoprotein (oxLDL), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), apolipoprotein (Apo)A-1 and ApoB levels. The VFA was evaluated on magnetic resonance imaging (MRI), and cardiorespiratory fitness was assessed by measuring the peak oxygen uptake (V4O2 peak). Results: The median 25(OH)D concentration was 35.6 nmol/L, and the prevalence of 25(OH)D deficiency was 78.7%. A multiple linear regression analysis revealed that the serum 25(OH)D concentration was inversely related to the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values, even after adjusting for age, season, smoking status, alcohol consumption, medication use, vitamin D intake, calcium intake, VFA and cardiorespiratory fitness. Conclusions: Serum 25(OH)D level is inversely correlated with the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values in Japanese men, independent of the VFA and cardiorespiratory fitness.

KW - Cardiorespiratory fitness

KW - Lipids

KW - Visceral fat

KW - Vitamin D

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