Ascorbic acid 2-phosphate enhances albumin mRNA expression and secretion of porcine hepatocytes

Dawei Yang, Toshie Koyama, Ai Okamura, Yoshiaki Shiba, Takayuki Akimoto, Makoto Kodama

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of ascorbic acid 2-phosphate (Asc2P) was tested on porcine and rat mature hepatocytes in vitro. Asc2P enhanced the porcine albumin mRNA expression. The albumin secretion released into the culture medium from the porcine hepatocytes was also increased by Asc2P. However, Asc2P did not give any effects to rat hepatocytes on albumin mRNA expression and albumin secretion. This result shows that Asc2P is one of the important factors to enhance porcine hepatocyte activity.

Original languageEnglish
Pages (from-to)323-327
Number of pages5
JournalMaterials Science and Engineering C
Volume24
Issue number3
DOIs
Publication statusPublished - 2004 Apr 1
Externally publishedYes

Fingerprint

secretions
ascorbic acid
Ascorbic acid
albumins
Albumins
phosphates
Phosphates
Messenger RNA
rats
Rats
culture media
Culture Media
Hepatocytes
ascorbate-2-phosphate

Keywords

  • Albumin
  • Albumin secretion
  • Ascorbic acid 2-phosphate
  • Enzyme-linked immunosorbent assay
  • Messenger RNA expression
  • Porcine hepatocytes
  • Rat hepatocytes
  • Reverse transcriptase-polymerase chain reaction

ASJC Scopus subject areas

  • Biomaterials

Cite this

Ascorbic acid 2-phosphate enhances albumin mRNA expression and secretion of porcine hepatocytes. / Yang, Dawei; Koyama, Toshie; Okamura, Ai; Shiba, Yoshiaki; Akimoto, Takayuki; Kodama, Makoto.

In: Materials Science and Engineering C, Vol. 24, No. 3, 01.04.2004, p. 323-327.

Research output: Contribution to journalArticle

Yang, Dawei ; Koyama, Toshie ; Okamura, Ai ; Shiba, Yoshiaki ; Akimoto, Takayuki ; Kodama, Makoto. / Ascorbic acid 2-phosphate enhances albumin mRNA expression and secretion of porcine hepatocytes. In: Materials Science and Engineering C. 2004 ; Vol. 24, No. 3. pp. 323-327.
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