Assessment of brain mechanisms involved in the processes of thermal sensation, pleasantness/unpleasantness, and evaluation

Yuka Aizawa, Tokiko Harada, Hiroki Nakata, Mizuki Tsunakawa, Norihiro Sadato, Kei Nagashima

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    The conscious perception of thermal stimuli is divided into two categories: thermal sensation (i.e., discriminative component) and pleasantness/unpleasantness (i.e., hedonic component). There have been very few studies which clearly dissociated the two components. The aim of the present study was 1) to identify brain regions involved in perception of thermal stimuli per se, dissociating those related to the two components, and additionally 2) to examine brain regions of the explicit evaluation processes for the two components. Sixteen participants received local thermal stimuli of either 41.5 °C or 18.0 °C during whole-body thermal stimuli of 47.0 °C, 32.0 °C, or 17.0 °C. The local stimuli were delivered to the right forearm with the Peltier device. The whole-body stimuli delivered through a water-perfusion suit was aimed to modulate thermal pleasantness/unpleasantness to the local stimulus. The local stimulation at the same temperature was conducted five times with 30-s intervals. Brain activation was assessed by functional magnetic resonance imaging (fMRI), and the participants were asked to report their ratings of thermal sensation and pleasantness/unpleasantness following the cessation of each local stimulus. Local thermal stimulation activated specific brain regions such as the anterior cingulate cortex, insula, and inferior parietal lobe, irrespective of the temperature of local and whole-body stimuli; however, no specific activation for hot or cold sensation was observed. Different brain regions were associated with pleasantness and unpleasantness; the caudate nucleus and frontal regions for pleasantness, and the medial frontal and anterior cingulate cortex for unpleasantness. In addition, the explicit evaluation process for the discriminative and hedonic components immediately following the cessation of local stimulus involved different brain regions; the medial prefrontal cortex extending to the anterior cingulate cortex, insula, middle frontal cortex, and parietal lobes during the explicit evaluation of thermal sensation, and the medial prefrontal cortex, posterior cingulate cortex, and inferior parietal lobes during that of pleasantness/unpleasantness.

    Original languageEnglish
    Pages (from-to)54-63
    Number of pages10
    JournalIBRO Reports
    Volume6
    DOIs
    Publication statusPublished - 2019 Jun 1

    Fingerprint

    Hot Temperature
    Brain
    Gyrus Cinguli
    Parietal Lobe
    Pleasure
    Frontal Lobe
    Prefrontal Cortex
    Temperature
    Caudate Nucleus
    Forearm
    Perfusion
    Magnetic Resonance Imaging
    Equipment and Supplies
    Water

    Keywords

    • Behavioral thermoregulation
    • Body temperature
    • Discriminative component
    • fMRI
    • Hedonic component
    • Insula
    • Prefrontal cortex
    • Thermal feeling
    • Thermal perception

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Assessment of brain mechanisms involved in the processes of thermal sensation, pleasantness/unpleasantness, and evaluation. / Aizawa, Yuka; Harada, Tokiko; Nakata, Hiroki; Tsunakawa, Mizuki; Sadato, Norihiro; Nagashima, Kei.

    In: IBRO Reports, Vol. 6, 01.06.2019, p. 54-63.

    Research output: Contribution to journalArticle

    Aizawa, Yuka ; Harada, Tokiko ; Nakata, Hiroki ; Tsunakawa, Mizuki ; Sadato, Norihiro ; Nagashima, Kei. / Assessment of brain mechanisms involved in the processes of thermal sensation, pleasantness/unpleasantness, and evaluation. In: IBRO Reports. 2019 ; Vol. 6. pp. 54-63.
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    abstract = "The conscious perception of thermal stimuli is divided into two categories: thermal sensation (i.e., discriminative component) and pleasantness/unpleasantness (i.e., hedonic component). There have been very few studies which clearly dissociated the two components. The aim of the present study was 1) to identify brain regions involved in perception of thermal stimuli per se, dissociating those related to the two components, and additionally 2) to examine brain regions of the explicit evaluation processes for the two components. Sixteen participants received local thermal stimuli of either 41.5 °C or 18.0 °C during whole-body thermal stimuli of 47.0 °C, 32.0 °C, or 17.0 °C. The local stimuli were delivered to the right forearm with the Peltier device. The whole-body stimuli delivered through a water-perfusion suit was aimed to modulate thermal pleasantness/unpleasantness to the local stimulus. The local stimulation at the same temperature was conducted five times with 30-s intervals. Brain activation was assessed by functional magnetic resonance imaging (fMRI), and the participants were asked to report their ratings of thermal sensation and pleasantness/unpleasantness following the cessation of each local stimulus. Local thermal stimulation activated specific brain regions such as the anterior cingulate cortex, insula, and inferior parietal lobe, irrespective of the temperature of local and whole-body stimuli; however, no specific activation for hot or cold sensation was observed. Different brain regions were associated with pleasantness and unpleasantness; the caudate nucleus and frontal regions for pleasantness, and the medial frontal and anterior cingulate cortex for unpleasantness. In addition, the explicit evaluation process for the discriminative and hedonic components immediately following the cessation of local stimulus involved different brain regions; the medial prefrontal cortex extending to the anterior cingulate cortex, insula, middle frontal cortex, and parietal lobes during the explicit evaluation of thermal sensation, and the medial prefrontal cortex, posterior cingulate cortex, and inferior parietal lobes during that of pleasantness/unpleasantness.",
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    AU - Sadato, Norihiro

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