Assessment of synchronization measures for effective ventricular support by using the shape memory alloy fibred artificial myocardium in goats

Y. Shiraishi, T. Yambe, Y. Saijo, F. Sato, A. Tanaka, M. Yoshizawa, T. K. Sugai, Y. Kaneko, Y. Sato, M. Uematsu, Mitsuo Umezu, T. Fujimoto, N. Masumoto, H. Liu, A. Baba, S. Konno, K. Tabayashi, H. Sasada, D. Homma

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    5 Citations (Scopus)

    Abstract

    Thromboembolic and haemorrhagic complications are the primary causes of mortality and morbidity in patients with artificial hearts, which are known to be induced by the interactions between blood flow and artificial material surfaces. The authors have been developing a new mechanical artificial myocardial assist device by using a sophisticated shape memory alloy fibre in order to achieve the mechanical cardiac support from outside of the heart without a direct blood contacting surface. The original material employed as the actuator of artificial myocardial assist devices was 100um fibred-shaped, which was composed of covalent and metallic bonding structure and designed to generate 4-7 % shortening by Joule heating induced by the electric current input. In this study, we focused on the synchronization of the actuator with native cardiac function, and the phase delay parameter was examined in animal experiments using Saanen goats. Total weight of the device including the actuator was around 150g, and the electric power was supplied transcutaneously. The device could be successfully installed into thoracic cavity, which was able to be girdling the left ventricle. The contraction of the device could be controlled by the originally designed microcomputer. The mechanical contraction signal input had been transmitted with the phase delay of 50-200 msec after the R-wave of ECG, and hemodynamic changes were investigated. Cardiac output and systolic left ventricular pressure were elevated with 20% delay of cardiac cycle by 27% and 7%, respectively, although there was smaller difference under the condition of the delay of over 30%. Therefore, it was suggested that the synchronization measures should be examined in order to achieve sophisticated ventricular passive/active support on physiological demand.

    Original languageEnglish
    Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
    Pages3047-3050
    Number of pages4
    DOIs
    Publication statusPublished - 2009
    Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN
    Duration: 2009 Sep 22009 Sep 6

    Other

    Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
    CityMinneapolis, MN
    Period09/9/209/9/6

    Fingerprint

    Shape memory effect
    Goats
    Myocardium
    Synchronization
    Actuators
    Equipment and Supplies
    Blood
    Artificial heart
    Joule heating
    Hemodynamics
    Electric currents
    Electrocardiography
    Microcomputers
    Animals
    Thoracic Cavity
    Artificial Heart
    Blood Substitutes
    Ventricular Pressure
    Fibers
    Cardiac Output

    ASJC Scopus subject areas

    • Cell Biology
    • Developmental Biology
    • Biomedical Engineering
    • Medicine(all)

    Cite this

    Shiraishi, Y., Yambe, T., Saijo, Y., Sato, F., Tanaka, A., Yoshizawa, M., ... Homma, D. (2009). Assessment of synchronization measures for effective ventricular support by using the shape memory alloy fibred artificial myocardium in goats. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 3047-3050). [5333627] https://doi.org/10.1109/IEMBS.2009.5333627

    Assessment of synchronization measures for effective ventricular support by using the shape memory alloy fibred artificial myocardium in goats. / Shiraishi, Y.; Yambe, T.; Saijo, Y.; Sato, F.; Tanaka, A.; Yoshizawa, M.; Sugai, T. K.; Kaneko, Y.; Sato, Y.; Uematsu, M.; Umezu, Mitsuo; Fujimoto, T.; Masumoto, N.; Liu, H.; Baba, A.; Konno, S.; Tabayashi, K.; Sasada, H.; Homma, D.

    Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 3047-3050 5333627.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Shiraishi, Y, Yambe, T, Saijo, Y, Sato, F, Tanaka, A, Yoshizawa, M, Sugai, TK, Kaneko, Y, Sato, Y, Uematsu, M, Umezu, M, Fujimoto, T, Masumoto, N, Liu, H, Baba, A, Konno, S, Tabayashi, K, Sasada, H & Homma, D 2009, Assessment of synchronization measures for effective ventricular support by using the shape memory alloy fibred artificial myocardium in goats. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5333627, pp. 3047-3050, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, 09/9/2. https://doi.org/10.1109/IEMBS.2009.5333627
    Shiraishi Y, Yambe T, Saijo Y, Sato F, Tanaka A, Yoshizawa M et al. Assessment of synchronization measures for effective ventricular support by using the shape memory alloy fibred artificial myocardium in goats. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 3047-3050. 5333627 https://doi.org/10.1109/IEMBS.2009.5333627
    Shiraishi, Y. ; Yambe, T. ; Saijo, Y. ; Sato, F. ; Tanaka, A. ; Yoshizawa, M. ; Sugai, T. K. ; Kaneko, Y. ; Sato, Y. ; Uematsu, M. ; Umezu, Mitsuo ; Fujimoto, T. ; Masumoto, N. ; Liu, H. ; Baba, A. ; Konno, S. ; Tabayashi, K. ; Sasada, H. ; Homma, D. / Assessment of synchronization measures for effective ventricular support by using the shape memory alloy fibred artificial myocardium in goats. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. pp. 3047-3050
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    abstract = "Thromboembolic and haemorrhagic complications are the primary causes of mortality and morbidity in patients with artificial hearts, which are known to be induced by the interactions between blood flow and artificial material surfaces. The authors have been developing a new mechanical artificial myocardial assist device by using a sophisticated shape memory alloy fibre in order to achieve the mechanical cardiac support from outside of the heart without a direct blood contacting surface. The original material employed as the actuator of artificial myocardial assist devices was 100um fibred-shaped, which was composed of covalent and metallic bonding structure and designed to generate 4-7 {\%} shortening by Joule heating induced by the electric current input. In this study, we focused on the synchronization of the actuator with native cardiac function, and the phase delay parameter was examined in animal experiments using Saanen goats. Total weight of the device including the actuator was around 150g, and the electric power was supplied transcutaneously. The device could be successfully installed into thoracic cavity, which was able to be girdling the left ventricle. The contraction of the device could be controlled by the originally designed microcomputer. The mechanical contraction signal input had been transmitted with the phase delay of 50-200 msec after the R-wave of ECG, and hemodynamic changes were investigated. Cardiac output and systolic left ventricular pressure were elevated with 20{\%} delay of cardiac cycle by 27{\%} and 7{\%}, respectively, although there was smaller difference under the condition of the delay of over 30{\%}. Therefore, it was suggested that the synchronization measures should be examined in order to achieve sophisticated ventricular passive/active support on physiological demand.",
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