Abstract
The release of catecholamines, dopamine and noradrenaline has been suggested to play a role in mediating ischemic damage in susceptible brain regions, the hippocampus and striatum. We now provide evidence that suggests a role for adrenoceptors in the deficit of 2-dcoxyglucosc uptake and CA1 field potential induced in hippocampal slices by hypoxia/hypoglycemia (ischemia). Treatment with α1- or β-adrenoceptor agonists or cAMP potentiated an ischemia-induced decline of both 2-deoxyglucose uptake and CA1 field potential in hippocampal slices, whereas α1- or β-adrenoceptor antagonists, or α2-adrenoceptor agonists produce a remarkable neuroprotective action against these deficits. The results indicate that stimulation of adrenoceptors may play a detrimental role in the development of ischemic damage, and suggest a neuroprotectivc action for adrenoceptor antagonists, which may lessen the functional deficits induced by ischemia.
| Original language | English |
|---|---|
| Pages (from-to) | 255-260 |
| Number of pages | 6 |
| Journal | European Journal of Pharmacology |
| Volume | 221 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 1992 Oct 20 |
| Externally published | Yes |
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Keywords
- (In vitro)
- 2-Deoxyglucose
- CA1 field potential
- Catecholamines
- Hippocampus
- Hypoxia/hypoglycemia
- Ischemia
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Assessment of the role of adrenoceptor function in ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potential in rat hippocampal slices. / Shibata, Shigenobu; Koutaroh, Kodama; Keiko, Tominaga; Showa, Ueki; Shigenori, Watanabe.
In: European Journal of Pharmacology, Vol. 221, No. 2-3, 20.10.1992, p. 255-260.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessment of the role of adrenoceptor function in ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potential in rat hippocampal slices
AU - Shibata, Shigenobu
AU - Koutaroh, Kodama
AU - Keiko, Tominaga
AU - Showa, Ueki
AU - Shigenori, Watanabe
PY - 1992/10/20
Y1 - 1992/10/20
N2 - The release of catecholamines, dopamine and noradrenaline has been suggested to play a role in mediating ischemic damage in susceptible brain regions, the hippocampus and striatum. We now provide evidence that suggests a role for adrenoceptors in the deficit of 2-dcoxyglucosc uptake and CA1 field potential induced in hippocampal slices by hypoxia/hypoglycemia (ischemia). Treatment with α1- or β-adrenoceptor agonists or cAMP potentiated an ischemia-induced decline of both 2-deoxyglucose uptake and CA1 field potential in hippocampal slices, whereas α1- or β-adrenoceptor antagonists, or α2-adrenoceptor agonists produce a remarkable neuroprotective action against these deficits. The results indicate that stimulation of adrenoceptors may play a detrimental role in the development of ischemic damage, and suggest a neuroprotectivc action for adrenoceptor antagonists, which may lessen the functional deficits induced by ischemia.
AB - The release of catecholamines, dopamine and noradrenaline has been suggested to play a role in mediating ischemic damage in susceptible brain regions, the hippocampus and striatum. We now provide evidence that suggests a role for adrenoceptors in the deficit of 2-dcoxyglucosc uptake and CA1 field potential induced in hippocampal slices by hypoxia/hypoglycemia (ischemia). Treatment with α1- or β-adrenoceptor agonists or cAMP potentiated an ischemia-induced decline of both 2-deoxyglucose uptake and CA1 field potential in hippocampal slices, whereas α1- or β-adrenoceptor antagonists, or α2-adrenoceptor agonists produce a remarkable neuroprotective action against these deficits. The results indicate that stimulation of adrenoceptors may play a detrimental role in the development of ischemic damage, and suggest a neuroprotectivc action for adrenoceptor antagonists, which may lessen the functional deficits induced by ischemia.
KW - (In vitro)
KW - 2-Deoxyglucose
KW - CA1 field potential
KW - Catecholamines
KW - Hippocampus
KW - Hypoxia/hypoglycemia
KW - Ischemia
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U2 - 10.1016/0014-2999(92)90710-L
DO - 10.1016/0014-2999(92)90710-L
M3 - Article
VL - 221
SP - 255
EP - 260
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2-3
ER -