Assessment of the role of adrenoceptor function in ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potential in rat hippocampal slices

Shibata Shigenobu, Kodama Koutaroh, Tominaga Keiko, Ueki Showa, Watanabe Shigenori

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The release of catecholamines, dopamine and noradrenaline has been suggested to play a role in mediating ischemic damage in susceptible brain regions, the hippocampus and striatum. We now provide evidence that suggests a role for adrenoceptors in the deficit of 2-dcoxyglucosc uptake and CA1 field potential induced in hippocampal slices by hypoxia/hypoglycemia (ischemia). Treatment with α1- or β-adrenoceptor agonists or cAMP potentiated an ischemia-induced decline of both 2-deoxyglucose uptake and CA1 field potential in hippocampal slices, whereas α1- or β-adrenoceptor antagonists, or α2-adrenoceptor agonists produce a remarkable neuroprotective action against these deficits. The results indicate that stimulation of adrenoceptors may play a detrimental role in the development of ischemic damage, and suggest a neuroprotectivc action for adrenoceptor antagonists, which may lessen the functional deficits induced by ischemia.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalEuropean Journal of Pharmacology
Volume221
Issue number2-3
DOIs
Publication statusPublished - 1992 Oct 20

Keywords

  • (In vitro)
  • 2-Deoxyglucose
  • CA1 field potential
  • Catecholamines
  • Hippocampus
  • Hypoxia/hypoglycemia
  • Ischemia

ASJC Scopus subject areas

  • Pharmacology

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