Association between serum 25-hydroxyvitamin d and inflammatory cytokines in healthy adults

Xiaomin Sun, Zhen Bo Cao, Yuping Zhang, Yoshiko Ishimi, Izumi Tabata, Mitsuru Higuchi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Here, we aimed to examine the associations between levels of serum 25-hydroxyvitamin D [25(OH)D] and inflammatory cytokines in healthy Japanese adults. A total of 95 healthy adults (61 women; age range 21-69 years) participated in our study. Fasting blood samples were analyzed for 25(OH)D, 1,25-dihydroxyvitamin D [1,25(OH)2D], interferon-γ (IFN-γ), interleukin-6 (IL-6), and interleukin-17 (IL-17) levels using enzyme-linked immunosorbent assays kits. Total percent body fat was determined by dual energy X-ray absorptiometry (DXA). Moderate to vigorous physical activity (MVPA) was assessed objectively using an activity monitor for 7 days. The mean 25(OH)D concentration was 34.7 nmol/L, and 83 subjects had 25(OH)D concentrations less than 50 nmol/L. Multiple linear regression analysis revealed that serum 25(OH)D level was positively related to plasma IL-17 level (β = 0.26, p = 0.025), after adjustment for gender, age, vitamin D intake, alcohol consumption, smoking status, and percent body fat. This relationship remained statistically significant (β = 0.28, p = 0.019) even after additional adjustment for MVPA. However, no significant association was found between serum 25(OH)D level and plasma IFN-γ or IL-6 levels. In conclusion, this study identified a high prevalence of vitamin D deficiency in healthy Japanese adults. Serum 25(OH)D level was positively related to IL-17 level, independent of physical activity.

Original languageEnglish
Pages (from-to)221-230
Number of pages10
JournalNutrients
Volume6
Issue number1
DOIs
Publication statusPublished - 2014 Jan 2

Fingerprint

blood serum
Interleukin-17
cytokines
physical activity
Cytokines
interferons
Exercise
Serum
interleukin-6
Interferons
body fat
Adipose Tissue
Interleukin-6
vitamin D deficiency
Vitamin D Deficiency
dual-energy X-ray absorptiometry
Photon Absorptiometry
vitamin D
Vitamin D
Alcohol Drinking

Keywords

  • Interferon-γ
  • Interleukin-17
  • Interleukin-6
  • Physical activity
  • Vitamin D

ASJC Scopus subject areas

  • Food Science

Cite this

Sun, X., Cao, Z. B., Zhang, Y., Ishimi, Y., Tabata, I., & Higuchi, M. (2014). Association between serum 25-hydroxyvitamin d and inflammatory cytokines in healthy adults. Nutrients, 6(1), 221-230. https://doi.org/10.3390/nu6010221

Association between serum 25-hydroxyvitamin d and inflammatory cytokines in healthy adults. / Sun, Xiaomin; Cao, Zhen Bo; Zhang, Yuping; Ishimi, Yoshiko; Tabata, Izumi; Higuchi, Mitsuru.

In: Nutrients, Vol. 6, No. 1, 02.01.2014, p. 221-230.

Research output: Contribution to journalArticle

Sun, X, Cao, ZB, Zhang, Y, Ishimi, Y, Tabata, I & Higuchi, M 2014, 'Association between serum 25-hydroxyvitamin d and inflammatory cytokines in healthy adults', Nutrients, vol. 6, no. 1, pp. 221-230. https://doi.org/10.3390/nu6010221
Sun, Xiaomin ; Cao, Zhen Bo ; Zhang, Yuping ; Ishimi, Yoshiko ; Tabata, Izumi ; Higuchi, Mitsuru. / Association between serum 25-hydroxyvitamin d and inflammatory cytokines in healthy adults. In: Nutrients. 2014 ; Vol. 6, No. 1. pp. 221-230.
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