Association between serum 25-hydroxyvitamin d and inflammatory cytokines in healthy adults

Xiaomin Sun, Zhen Bo Cao, Yuping Zhang, Yoshiko Ishimi, Izumi Tabata, Mitsuru Higuchi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Here, we aimed to examine the associations between levels of serum 25-hydroxyvitamin D [25(OH)D] and inflammatory cytokines in healthy Japanese adults. A total of 95 healthy adults (61 women; age range 21-69 years) participated in our study. Fasting blood samples were analyzed for 25(OH)D, 1,25-dihydroxyvitamin D [1,25(OH)2D], interferon-γ (IFN-γ), interleukin-6 (IL-6), and interleukin-17 (IL-17) levels using enzyme-linked immunosorbent assays kits. Total percent body fat was determined by dual energy X-ray absorptiometry (DXA). Moderate to vigorous physical activity (MVPA) was assessed objectively using an activity monitor for 7 days. The mean 25(OH)D concentration was 34.7 nmol/L, and 83 subjects had 25(OH)D concentrations less than 50 nmol/L. Multiple linear regression analysis revealed that serum 25(OH)D level was positively related to plasma IL-17 level (β = 0.26, p = 0.025), after adjustment for gender, age, vitamin D intake, alcohol consumption, smoking status, and percent body fat. This relationship remained statistically significant (β = 0.28, p = 0.019) even after additional adjustment for MVPA. However, no significant association was found between serum 25(OH)D level and plasma IFN-γ or IL-6 levels. In conclusion, this study identified a high prevalence of vitamin D deficiency in healthy Japanese adults. Serum 25(OH)D level was positively related to IL-17 level, independent of physical activity.

Original languageEnglish
Pages (from-to)221-230
Number of pages10
JournalNutrients
Volume6
Issue number1
DOIs
Publication statusPublished - 2014 Jan 2

Keywords

  • Interferon-γ
  • Interleukin-17
  • Interleukin-6
  • Physical activity
  • Vitamin D

ASJC Scopus subject areas

  • Food Science

Fingerprint Dive into the research topics of 'Association between serum 25-hydroxyvitamin d and inflammatory cytokines in healthy adults'. Together they form a unique fingerprint.

  • Cite this

    Sun, X., Cao, Z. B., Zhang, Y., Ishimi, Y., Tabata, I., & Higuchi, M. (2014). Association between serum 25-hydroxyvitamin d and inflammatory cytokines in healthy adults. Nutrients, 6(1), 221-230. https://doi.org/10.3390/nu6010221