Association of body mass index-related single nucleotide polymorphisms with psychiatric disease and memory performance in a Japanese population

Midori Ninomiya-Baba, Junko Matsuo, Daimei Sasayama, Hiroaki Hori, Toshiya Teraishi, Miho Ota, Kotaro Hattori, Takamasa Noda, Ikki Ishida, Shigenobu Shibata, Hiroshi Kunugi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: Obesity is a risk factor for psychiatric diseases. Recently, a number of single nucleotide polymorphisms (SNPs) have been shown to be related to body mass index (BMI). In this study, we investigated the association of BMI-related SNPs with psychiatric diseases and one of their endophenotypes, memory performance, in a Japanese population. Methods: The subjects were 1624 patients with one of three psychiatric diseases (799 patients with major depressive disorder, 594 with schizophrenia, and 231 with bipolar disorder) and 1189 healthy controls. Memory performance was assessed using the Wechsler Memory Scale – Revised (WMS-R). Genomic DNA was prepared from venous blood and used to genotype 23 BMI-related SNPs using the TaqMan 5′-exonuclease allelic discrimination assay. We then analysed the relationships between the SNPs and psychiatric disease and various subscales of the WMS-R. Results: Three SNPs (rs11142387, rs12597579, and rs6548238) showed significant differences in the genotype or allele frequency between patients with any psychiatric diseases and controls. Furthermore, six SNPs (rs11142387, rs12597579, rs2815752, rs2074356, rs4776970, and rs2287019) showed significant differences in at least one subscale of the WMS-R depending on the genotypes of the healthy controls. Interestingly, rs11142387 near the Kruppel-like factor 9 (KLF9) was significantly associated with psychiatric disease and poor memory function. Conclusions: We identified three and six BMI-related SNPs associated with psychiatric disease and memory performance, respectively. In particular, carrying the A allele of rs11142387 near KLF9 was found to be associated with psychiatric disease and poor memory performance, which warrants further investigations.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalActa Neuropsychiatrica
DOIs
Publication statusAccepted/In press - 2016 Dec 7
Externally publishedYes

Fingerprint

Single Nucleotide Polymorphism
Psychiatry
Body Mass Index
Population
Kruppel-Like Transcription Factors
Wechsler Scales
Genotype
Phosphodiesterase I
Endophenotypes
Major Depressive Disorder
Bipolar Disorder
Gene Frequency
Schizophrenia
Obesity
Alleles
DNA

Keywords

  • BMI
  • memory
  • psychiatric disorders
  • SNP
  • Wechsler Memory Scale – Revised

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Association of body mass index-related single nucleotide polymorphisms with psychiatric disease and memory performance in a Japanese population. / Ninomiya-Baba, Midori; Matsuo, Junko; Sasayama, Daimei; Hori, Hiroaki; Teraishi, Toshiya; Ota, Miho; Hattori, Kotaro; Noda, Takamasa; Ishida, Ikki; Shibata, Shigenobu; Kunugi, Hiroshi.

In: Acta Neuropsychiatrica, 07.12.2016, p. 1-10.

Research output: Contribution to journalArticle

Ninomiya-Baba, Midori ; Matsuo, Junko ; Sasayama, Daimei ; Hori, Hiroaki ; Teraishi, Toshiya ; Ota, Miho ; Hattori, Kotaro ; Noda, Takamasa ; Ishida, Ikki ; Shibata, Shigenobu ; Kunugi, Hiroshi. / Association of body mass index-related single nucleotide polymorphisms with psychiatric disease and memory performance in a Japanese population. In: Acta Neuropsychiatrica. 2016 ; pp. 1-10.
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AU - Ninomiya-Baba, Midori

AU - Matsuo, Junko

AU - Sasayama, Daimei

AU - Hori, Hiroaki

AU - Teraishi, Toshiya

AU - Ota, Miho

AU - Hattori, Kotaro

AU - Noda, Takamasa

AU - Ishida, Ikki

AU - Shibata, Shigenobu

AU - Kunugi, Hiroshi

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N2 - Objective: Obesity is a risk factor for psychiatric diseases. Recently, a number of single nucleotide polymorphisms (SNPs) have been shown to be related to body mass index (BMI). In this study, we investigated the association of BMI-related SNPs with psychiatric diseases and one of their endophenotypes, memory performance, in a Japanese population. Methods: The subjects were 1624 patients with one of three psychiatric diseases (799 patients with major depressive disorder, 594 with schizophrenia, and 231 with bipolar disorder) and 1189 healthy controls. Memory performance was assessed using the Wechsler Memory Scale – Revised (WMS-R). Genomic DNA was prepared from venous blood and used to genotype 23 BMI-related SNPs using the TaqMan 5′-exonuclease allelic discrimination assay. We then analysed the relationships between the SNPs and psychiatric disease and various subscales of the WMS-R. Results: Three SNPs (rs11142387, rs12597579, and rs6548238) showed significant differences in the genotype or allele frequency between patients with any psychiatric diseases and controls. Furthermore, six SNPs (rs11142387, rs12597579, rs2815752, rs2074356, rs4776970, and rs2287019) showed significant differences in at least one subscale of the WMS-R depending on the genotypes of the healthy controls. Interestingly, rs11142387 near the Kruppel-like factor 9 (KLF9) was significantly associated with psychiatric disease and poor memory function. Conclusions: We identified three and six BMI-related SNPs associated with psychiatric disease and memory performance, respectively. In particular, carrying the A allele of rs11142387 near KLF9 was found to be associated with psychiatric disease and poor memory performance, which warrants further investigations.

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