Association of impaired neuronal migration with cognitive deficits in extremely preterm infants

Ken Ichiro Kubo, Kimiko Deguchi, Taku Nagai, Yukiko Ito, Keitaro Yoshida, Toshihiro Endo, Seico Benner, Wei Shan, Ayako Kitazawa, Michihiko Aramaki, Kazuhiro Ishii, Minkyung Shin, Yuki Matsunaga, Kanehiro Hayashi, Masaki Kakeyama, Chiharu Tohyama, Kenji F. Tanaka, Kohichi Tanaka, Sachio Takashima, Masahiro Nakayama & 7 others Masayuki Itoh, Yukio Hirata, Barbara Antalffy, Dawna D. Armstrong, Kiyofumi Yamada, Ken Inoue, Kazunori Nakajima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Many extremely preterm infants (born before 28 gestational weeks [GWs]) develop cognitive impairment in later life, although the underlying pathogenesis is not yet completely understood. Our examinations of the developing human neocortex confirmed that neuronal migration continues beyond 23 GWs, the gestational week at which extremely preterm infants have live births. We observed larger numbers of ectopic neurons in the white matter of the neocortex in human extremely preterm infants with brain injury and hypothesized that altered neuronal migration may be associated with cognitive impairment in later life. To confirm whether preterm brain injury affects neuronal migration, we produced brain damage in mouse embryos by occluding the maternal uterine arteries. The mice showed delayed neuronal migration, ectopic neurons in the white matter, altered neuronal alignment, and abnormal corticocortical axonal wiring. Similar to human extremely preterm infants with brain injury, the surviving mice exhibited cognitive deficits. Activation of the affected medial prefrontal cortices of the surviving mice improved working memory deficits, indicating that decreased neuronal activity caused the cognitive deficits. These findings suggest that altered neuronal migration altered by brain injury might contribute to the subsequent development of cognitive impairment in extremely preterm infants.

Original languageEnglish
JournalJCI insight
Volume2
Issue number10
DOIs
Publication statusPublished - 2017 May 18

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Extremely Premature Infants
Brain Injuries
Neocortex
Neurons
Uterine Artery
Memory Disorders
Live Birth
Prefrontal Cortex
Short-Term Memory
Embryonic Structures
Mothers
Brain
Cognitive Dysfunction

Keywords

  • Development
  • Neuroscience

Cite this

Kubo, K. I., Deguchi, K., Nagai, T., Ito, Y., Yoshida, K., Endo, T., ... Nakajima, K. (2017). Association of impaired neuronal migration with cognitive deficits in extremely preterm infants. JCI insight, 2(10). https://doi.org/10.1172/jci.insight.88609

Association of impaired neuronal migration with cognitive deficits in extremely preterm infants. / Kubo, Ken Ichiro; Deguchi, Kimiko; Nagai, Taku; Ito, Yukiko; Yoshida, Keitaro; Endo, Toshihiro; Benner, Seico; Shan, Wei; Kitazawa, Ayako; Aramaki, Michihiko; Ishii, Kazuhiro; Shin, Minkyung; Matsunaga, Yuki; Hayashi, Kanehiro; Kakeyama, Masaki; Tohyama, Chiharu; Tanaka, Kenji F.; Tanaka, Kohichi; Takashima, Sachio; Nakayama, Masahiro; Itoh, Masayuki; Hirata, Yukio; Antalffy, Barbara; Armstrong, Dawna D.; Yamada, Kiyofumi; Inoue, Ken; Nakajima, Kazunori.

In: JCI insight, Vol. 2, No. 10, 18.05.2017.

Research output: Contribution to journalArticle

Kubo, KI, Deguchi, K, Nagai, T, Ito, Y, Yoshida, K, Endo, T, Benner, S, Shan, W, Kitazawa, A, Aramaki, M, Ishii, K, Shin, M, Matsunaga, Y, Hayashi, K, Kakeyama, M, Tohyama, C, Tanaka, KF, Tanaka, K, Takashima, S, Nakayama, M, Itoh, M, Hirata, Y, Antalffy, B, Armstrong, DD, Yamada, K, Inoue, K & Nakajima, K 2017, 'Association of impaired neuronal migration with cognitive deficits in extremely preterm infants', JCI insight, vol. 2, no. 10. https://doi.org/10.1172/jci.insight.88609
Kubo, Ken Ichiro ; Deguchi, Kimiko ; Nagai, Taku ; Ito, Yukiko ; Yoshida, Keitaro ; Endo, Toshihiro ; Benner, Seico ; Shan, Wei ; Kitazawa, Ayako ; Aramaki, Michihiko ; Ishii, Kazuhiro ; Shin, Minkyung ; Matsunaga, Yuki ; Hayashi, Kanehiro ; Kakeyama, Masaki ; Tohyama, Chiharu ; Tanaka, Kenji F. ; Tanaka, Kohichi ; Takashima, Sachio ; Nakayama, Masahiro ; Itoh, Masayuki ; Hirata, Yukio ; Antalffy, Barbara ; Armstrong, Dawna D. ; Yamada, Kiyofumi ; Inoue, Ken ; Nakajima, Kazunori. / Association of impaired neuronal migration with cognitive deficits in extremely preterm infants. In: JCI insight. 2017 ; Vol. 2, No. 10.
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AU - Hirata, Yukio

AU - Antalffy, Barbara

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AU - Inoue, Ken

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