TY - JOUR
T1 - Association of the interaction between physical activity and sitting time with mortality in older Japanese adults
AU - Watanabe, Daiki
AU - Yamada, Yosuke
AU - Yoshida, Tsukasa
AU - Watanabe, Yuya
AU - Hatamoto, Yoichi
AU - Fujita, Hiroyuki
AU - Miyachi, Motohiko
AU - Kimura, Misaka
N1 - Funding Information:
The Kyoto–Kameoka study was conducted with JSPS KAKENHI and was supported by a research grant provided to Misaka Kimura (24240091), Yosuke Yamada (15H05363), and Daiki Watanabe (21 K17699); a grant and administrative support by the Kyoto Prefecture Community‐based Integrated older adults Care Systems Promotion Organization since 2011; Kameoka City under the program of the Long‐term Care Insurance and Planning Division of the Health and Welfare Bureau for the older adults, Ministry of Health, Labour, and Welfare and the World Health Organization (WHO) Collaborating Centre on Community Safety Promotion.
Publisher Copyright:
© 2022 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.
PY - 2022/12
Y1 - 2022/12
N2 - Purpose: To examine how physical activity (PA) and sitting time (ST) are associated with mortality in older Japanese adults. Methodology: We used the data of 10 233 older Japanese adults aged ≥65 years who provided valid responses to the International Physical Activity Questionnaire-Short Form (IPAQ-SF) by a mail survey. Both PA and ST were assessed using the IPAQ-SF. The results were classified into high or low categories using ≥3.0 metabolic equivalent PA (150 min/week) and ST (300 min/day) into the following four groups: High PA (HPA)/Low ST (LST), HPA/High ST (HST), Low PA (LPA)/LST, and LPA/HST. Mortality data were collected from July 30, 2011, to November 30, 2016. We assessed the interaction of PA and ST status with the risk of all-cause mortality using the multivariable Cox proportional-hazards model. Results: A total of 1014 people were recorded to have died during a median follow-up period of 5.3 years (51 553 person-years). After adjustment for confounders, the risk of mortality was higher in the LPA/HST group than in all other groups (HPA/LST: reference; HPA/HST group: hazard ratio [HR] 0.86 (95% confidence interval [CI]: 0.66 to 1.12); LPA/LST group: HR 1.09 (95% CI: 0.88 to 1.35); LPA/HST group: HR 1.36 (95% CI: 1.10 to 1.67); and multiplicative interaction: HR 1.44 (95% CI: 1.07 to 1.94)). Conclusions: The risk of mortality associated with LPA/HST depends on the level of PA, duration of ST, and their interaction with each other. Our results may be useful in ameliorating the adverse effects leading to mortality in individuals with lower PA, by reducing ST.
AB - Purpose: To examine how physical activity (PA) and sitting time (ST) are associated with mortality in older Japanese adults. Methodology: We used the data of 10 233 older Japanese adults aged ≥65 years who provided valid responses to the International Physical Activity Questionnaire-Short Form (IPAQ-SF) by a mail survey. Both PA and ST were assessed using the IPAQ-SF. The results were classified into high or low categories using ≥3.0 metabolic equivalent PA (150 min/week) and ST (300 min/day) into the following four groups: High PA (HPA)/Low ST (LST), HPA/High ST (HST), Low PA (LPA)/LST, and LPA/HST. Mortality data were collected from July 30, 2011, to November 30, 2016. We assessed the interaction of PA and ST status with the risk of all-cause mortality using the multivariable Cox proportional-hazards model. Results: A total of 1014 people were recorded to have died during a median follow-up period of 5.3 years (51 553 person-years). After adjustment for confounders, the risk of mortality was higher in the LPA/HST group than in all other groups (HPA/LST: reference; HPA/HST group: hazard ratio [HR] 0.86 (95% confidence interval [CI]: 0.66 to 1.12); LPA/LST group: HR 1.09 (95% CI: 0.88 to 1.35); LPA/HST group: HR 1.36 (95% CI: 1.10 to 1.67); and multiplicative interaction: HR 1.44 (95% CI: 1.07 to 1.94)). Conclusions: The risk of mortality associated with LPA/HST depends on the level of PA, duration of ST, and their interaction with each other. Our results may be useful in ameliorating the adverse effects leading to mortality in individuals with lower PA, by reducing ST.
KW - International Physical Activity Questionnaire-Short Form
KW - mortality
KW - multiplicative interaction
KW - older adults
KW - physical activity
KW - population-based longitudinal cohort study
KW - relative excess risk due to interaction
KW - sitting time
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U2 - 10.1111/sms.14234
DO - 10.1111/sms.14234
M3 - Article
C2 - 36112073
AN - SCOPUS:85138623887
VL - 32
SP - 1757
EP - 1767
JO - Scandinavian Journal of Medicine and Science in Sports
JF - Scandinavian Journal of Medicine and Science in Sports
SN - 0905-7188
IS - 12
ER -