Associations between sleep quality and inflammatory markers in patients with schizophrenia

Shih Hua Fang, Katsuhiko Suzuki, Chin Leong Lim, Ming Shun Chung, Po Wen Ku, Li Jung Chen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Sleep disorder is a risk factor for several systemic inflammation-related diseases and there are extensive data showing that schizophrenia is associated with chronic low-grade systemic inflammation. This study investigated the associations between sleep quality and inflammatory markers in patients with schizophrenia, which has not been examined before. Sleep quality (total sleep time, sleep efficiency, sleep onset latency, total activity counts, wake after sleep onset, number of awakening, and average length of awakening) was measured using actigraphy in 199 schizophrenia inpatients. The state of inflammation was measured using blood concentration of white blood cells (WBC) and neutrophils, together with neutrophil–lymphocyte ratio (NLR), and platelet–lymphocyte ratio (PLR). The results showed that total sleep time was negatively associated with NLR and PLR, and sleep efficiency was negatively associated with neutrophil counts and NLR. Sleep onset latency, total activity counts, wake after sleep onset, and number of awakening were positively associated with WBC and neutrophil counts. The average length of awakening was positively associated with NLR and PLR. This is the first report to suggest that improving sleep quality may modulate the state of inflammation in patients with schizophrenia.

Original languageEnglish
Pages (from-to)154-160
Number of pages7
JournalPsychiatry Research
Volume246
DOIs
Publication statusPublished - 2016 Dec 30

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Schizophrenia
Sleep
Inflammation
Neutrophils
Actigraphy
Leukocyte Count
Inpatients
Leukocytes

Keywords

  • Actigraphy
  • Insomnia
  • Neutrophil–lymphocyte ratio
  • Platelet–lymphocyte ratio
  • White blood cell

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Associations between sleep quality and inflammatory markers in patients with schizophrenia. / Fang, Shih Hua; Suzuki, Katsuhiko; Lim, Chin Leong; Chung, Ming Shun; Ku, Po Wen; Chen, Li Jung.

In: Psychiatry Research, Vol. 246, 30.12.2016, p. 154-160.

Research output: Contribution to journalArticle

Fang, Shih Hua ; Suzuki, Katsuhiko ; Lim, Chin Leong ; Chung, Ming Shun ; Ku, Po Wen ; Chen, Li Jung. / Associations between sleep quality and inflammatory markers in patients with schizophrenia. In: Psychiatry Research. 2016 ; Vol. 246. pp. 154-160.
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