Associations of adiponectin with sex hormone-binding globulin levels in aging male and female populations

Toshiyuki Yasui, Junko Tomita, Yuka Miyatani, Masayo Yamada, Hirokazu Uemura, Minoru Irahara, Makoto Arai, Noriko Kojimahara, Ryugo Okabe, Yasutomo Ishii, Shin ichi Tashiro, Hiroshi Sato

    Research output: Contribution to journalArticle

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    Abstract

    Background: Changes with aging in serum gonadal hormones, sex hormone-binding globulin (SHBG) and adiponectin, which are involved in insulin resistance and metabolic syndrome, are different in men and women. We examined the relationships of serum adiponectin concentrations with serum concentrations of hormones and SHBG in men and women. Methods: One hundred fifty-four men and 180 women aged from 50 to 85 years were included in the cross-sectional study. Serum concentrations of testosterone, estradiol, dehydroepiandrosterone-sulfate, SHBG and adiponectin were measured in men and women. Results: Serum adiponectin concentration showed a significant positive correlation with serum SHBG concentration in men and women (r = 0.404, p < 0.0001 and r = 0.348, p < 0.0001, respectively). Multiple regression analysis also showed that SHBG was the significant predictor for adiponectin in men and women. Serum adiponectin concentration in men showed a significant positive correlation with total testosterone concentration, but that in women was not significantly correlated with total testosterone concentration. Both adiponectin and SHBG concentrations in men (r = - 0.222, p = 0.0051 and r = - 0.334, p < 0.0001, respectively) and women (r = - 0.281, p = 0.0014 and r = - 0.251, p = 0.0048, respectively) showed significant negative correlations with the homeostasis model assessment (HOMA) index. Conclusion: Correlations between adiponectin and SHBG were significantly positive in both men and women, and both adiponectin and SHBG might be involved in insulin resistance in both sexes.

    Original languageEnglish
    Pages (from-to)69-75
    Number of pages7
    JournalClinica Chimica Acta
    Volume386
    Issue number1-2
    DOIs
    Publication statusPublished - 2007 Nov

    Fingerprint

    Sex Hormone-Binding Globulin
    Adiponectin
    Aging of materials
    Population
    Serum
    Testosterone
    Insulin Resistance
    Insulin
    Gonadal Hormones
    Serum Globulins
    Dehydroepiandrosterone Sulfate
    Hormones
    Regression analysis
    Estradiol
    Homeostasis
    Cross-Sectional Studies
    Regression Analysis

    Keywords

    • Adiponectin
    • Gender
    • SHBG

    ASJC Scopus subject areas

    • Biochemistry
    • Clinical Biochemistry

    Cite this

    Yasui, T., Tomita, J., Miyatani, Y., Yamada, M., Uemura, H., Irahara, M., ... Sato, H. (2007). Associations of adiponectin with sex hormone-binding globulin levels in aging male and female populations. Clinica Chimica Acta, 386(1-2), 69-75. https://doi.org/10.1016/j.cca.2007.08.001

    Associations of adiponectin with sex hormone-binding globulin levels in aging male and female populations. / Yasui, Toshiyuki; Tomita, Junko; Miyatani, Yuka; Yamada, Masayo; Uemura, Hirokazu; Irahara, Minoru; Arai, Makoto; Kojimahara, Noriko; Okabe, Ryugo; Ishii, Yasutomo; Tashiro, Shin ichi; Sato, Hiroshi.

    In: Clinica Chimica Acta, Vol. 386, No. 1-2, 11.2007, p. 69-75.

    Research output: Contribution to journalArticle

    Yasui, T, Tomita, J, Miyatani, Y, Yamada, M, Uemura, H, Irahara, M, Arai, M, Kojimahara, N, Okabe, R, Ishii, Y, Tashiro, SI & Sato, H 2007, 'Associations of adiponectin with sex hormone-binding globulin levels in aging male and female populations', Clinica Chimica Acta, vol. 386, no. 1-2, pp. 69-75. https://doi.org/10.1016/j.cca.2007.08.001
    Yasui, Toshiyuki ; Tomita, Junko ; Miyatani, Yuka ; Yamada, Masayo ; Uemura, Hirokazu ; Irahara, Minoru ; Arai, Makoto ; Kojimahara, Noriko ; Okabe, Ryugo ; Ishii, Yasutomo ; Tashiro, Shin ichi ; Sato, Hiroshi. / Associations of adiponectin with sex hormone-binding globulin levels in aging male and female populations. In: Clinica Chimica Acta. 2007 ; Vol. 386, No. 1-2. pp. 69-75.
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    abstract = "Background: Changes with aging in serum gonadal hormones, sex hormone-binding globulin (SHBG) and adiponectin, which are involved in insulin resistance and metabolic syndrome, are different in men and women. We examined the relationships of serum adiponectin concentrations with serum concentrations of hormones and SHBG in men and women. Methods: One hundred fifty-four men and 180 women aged from 50 to 85 years were included in the cross-sectional study. Serum concentrations of testosterone, estradiol, dehydroepiandrosterone-sulfate, SHBG and adiponectin were measured in men and women. Results: Serum adiponectin concentration showed a significant positive correlation with serum SHBG concentration in men and women (r = 0.404, p < 0.0001 and r = 0.348, p < 0.0001, respectively). Multiple regression analysis also showed that SHBG was the significant predictor for adiponectin in men and women. Serum adiponectin concentration in men showed a significant positive correlation with total testosterone concentration, but that in women was not significantly correlated with total testosterone concentration. Both adiponectin and SHBG concentrations in men (r = - 0.222, p = 0.0051 and r = - 0.334, p < 0.0001, respectively) and women (r = - 0.281, p = 0.0014 and r = - 0.251, p = 0.0048, respectively) showed significant negative correlations with the homeostasis model assessment (HOMA) index. Conclusion: Correlations between adiponectin and SHBG were significantly positive in both men and women, and both adiponectin and SHBG might be involved in insulin resistance in both sexes.",
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    author = "Toshiyuki Yasui and Junko Tomita and Yuka Miyatani and Masayo Yamada and Hirokazu Uemura and Minoru Irahara and Makoto Arai and Noriko Kojimahara and Ryugo Okabe and Yasutomo Ishii and Tashiro, {Shin ichi} and Hiroshi Sato",
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    AU - Tomita, Junko

    AU - Miyatani, Yuka

    AU - Yamada, Masayo

    AU - Uemura, Hirokazu

    AU - Irahara, Minoru

    AU - Arai, Makoto

    AU - Kojimahara, Noriko

    AU - Okabe, Ryugo

    AU - Ishii, Yasutomo

    AU - Tashiro, Shin ichi

    AU - Sato, Hiroshi

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    N2 - Background: Changes with aging in serum gonadal hormones, sex hormone-binding globulin (SHBG) and adiponectin, which are involved in insulin resistance and metabolic syndrome, are different in men and women. We examined the relationships of serum adiponectin concentrations with serum concentrations of hormones and SHBG in men and women. Methods: One hundred fifty-four men and 180 women aged from 50 to 85 years were included in the cross-sectional study. Serum concentrations of testosterone, estradiol, dehydroepiandrosterone-sulfate, SHBG and adiponectin were measured in men and women. Results: Serum adiponectin concentration showed a significant positive correlation with serum SHBG concentration in men and women (r = 0.404, p < 0.0001 and r = 0.348, p < 0.0001, respectively). Multiple regression analysis also showed that SHBG was the significant predictor for adiponectin in men and women. Serum adiponectin concentration in men showed a significant positive correlation with total testosterone concentration, but that in women was not significantly correlated with total testosterone concentration. Both adiponectin and SHBG concentrations in men (r = - 0.222, p = 0.0051 and r = - 0.334, p < 0.0001, respectively) and women (r = - 0.281, p = 0.0014 and r = - 0.251, p = 0.0048, respectively) showed significant negative correlations with the homeostasis model assessment (HOMA) index. Conclusion: Correlations between adiponectin and SHBG were significantly positive in both men and women, and both adiponectin and SHBG might be involved in insulin resistance in both sexes.

    AB - Background: Changes with aging in serum gonadal hormones, sex hormone-binding globulin (SHBG) and adiponectin, which are involved in insulin resistance and metabolic syndrome, are different in men and women. We examined the relationships of serum adiponectin concentrations with serum concentrations of hormones and SHBG in men and women. Methods: One hundred fifty-four men and 180 women aged from 50 to 85 years were included in the cross-sectional study. Serum concentrations of testosterone, estradiol, dehydroepiandrosterone-sulfate, SHBG and adiponectin were measured in men and women. Results: Serum adiponectin concentration showed a significant positive correlation with serum SHBG concentration in men and women (r = 0.404, p < 0.0001 and r = 0.348, p < 0.0001, respectively). Multiple regression analysis also showed that SHBG was the significant predictor for adiponectin in men and women. Serum adiponectin concentration in men showed a significant positive correlation with total testosterone concentration, but that in women was not significantly correlated with total testosterone concentration. Both adiponectin and SHBG concentrations in men (r = - 0.222, p = 0.0051 and r = - 0.334, p < 0.0001, respectively) and women (r = - 0.281, p = 0.0014 and r = - 0.251, p = 0.0048, respectively) showed significant negative correlations with the homeostasis model assessment (HOMA) index. Conclusion: Correlations between adiponectin and SHBG were significantly positive in both men and women, and both adiponectin and SHBG might be involved in insulin resistance in both sexes.

    KW - Adiponectin

    KW - Gender

    KW - SHBG

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