Associations of endogenous sex hormones and sex hormone-binding globulin with lipid profiles in aged Japanese men and women

Toshiyuki Yasui, Hirokazu Uemura, Minoru Irahara, Makoto Arai, Noriko Kojimahara, Ryugo Okabe, Yasutomo Ishii, Shin ichi Tashiro, Hiroshi Sato

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    Background: The associations of endogenous estrogen with lipid profiles and insulin resistance were conflicting in both men and women. We determined the associations of serum estradiol level and free estradiol index (FEI) with lipid profiles and insulin resistance in aged Japanese men and women. Methods: One hundred seventy-four men and 208 postmenopausal women aged from 50 to 85 y were included in this study. Lipid profiles, fasting glucose and insulin as well as estradiol, testosterone, dehydroepiandrosterone-sulfate (DHEA-S) and sex hormone-binding globulin (SHBG) in serum were measured. Results: Serum estradiol concentration in men showed a significant and negative correlation with high density lipoprotein-cholesterol (HDL-C) concentration and a significant and positive correlation with triglyceride (TG) after adjustment for age and body mass index (BMI). In addition, estradiol level was positively correlated with insulin and HOMA index. In women, serum levels of estradiol and testosterone were not correlated with lipid profiles and insulin resistance. SHBG concentration was negatively correlated with TG after adjustment for age and BMI in women. Conclusion: Endogenous estradiol level is associated with unfavorable lipid profiles and insulin resistance in aged men. In aged women, SHBG level is associated with favorable lipid profiles.

    Original languageEnglish
    Pages (from-to)43-47
    Number of pages5
    JournalClinica Chimica Acta
    Volume398
    Issue number1-2
    DOIs
    Publication statusPublished - 2008 Dec

    Fingerprint

    Sex Hormone-Binding Globulin
    Gonadal Steroid Hormones
    Estradiol
    Lipids
    Insulin
    Insulin Resistance
    Serum
    Testosterone
    Triglycerides
    Body Mass Index
    Dehydroepiandrosterone Sulfate
    HDL Cholesterol
    Fasting
    Estrogens
    Glucose

    Keywords

    • Estradiol
    • Gender
    • Lipid metabolism

    ASJC Scopus subject areas

    • Biochemistry
    • Clinical Biochemistry
    • Biochemistry, medical

    Cite this

    Associations of endogenous sex hormones and sex hormone-binding globulin with lipid profiles in aged Japanese men and women. / Yasui, Toshiyuki; Uemura, Hirokazu; Irahara, Minoru; Arai, Makoto; Kojimahara, Noriko; Okabe, Ryugo; Ishii, Yasutomo; Tashiro, Shin ichi; Sato, Hiroshi.

    In: Clinica Chimica Acta, Vol. 398, No. 1-2, 12.2008, p. 43-47.

    Research output: Contribution to journalArticle

    Yasui, T, Uemura, H, Irahara, M, Arai, M, Kojimahara, N, Okabe, R, Ishii, Y, Tashiro, SI & Sato, H 2008, 'Associations of endogenous sex hormones and sex hormone-binding globulin with lipid profiles in aged Japanese men and women', Clinica Chimica Acta, vol. 398, no. 1-2, pp. 43-47. https://doi.org/10.1016/j.cca.2008.08.006
    Yasui, Toshiyuki ; Uemura, Hirokazu ; Irahara, Minoru ; Arai, Makoto ; Kojimahara, Noriko ; Okabe, Ryugo ; Ishii, Yasutomo ; Tashiro, Shin ichi ; Sato, Hiroshi. / Associations of endogenous sex hormones and sex hormone-binding globulin with lipid profiles in aged Japanese men and women. In: Clinica Chimica Acta. 2008 ; Vol. 398, No. 1-2. pp. 43-47.
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