Associations of intramyocellular lipid in vastus lateralis and biceps femoris with blood free fatty acid and muscle strength differ between young and elderly adults

Maya Hioki, Nana Kanehira, Teruhiko Koike, Akira Saito, Hideyuki Takahashi, Kiyoshi Shimaoka, Hisataka Sakakibara, Yoshiharu Oshida, Hiroshi Akima

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The present study aimed to determine relationships between intramyocellular lipid and biochemical profiles or muscle strength in elderly (n = 15; mean age, 71 years) and young (n = 15; mean age, 21 years) male and female adults. Levels of intramyocellular lipid in the vastus lateralis and biceps femoris muscles were determined using 1H-magnetic resonance spectroscopy. Fasting blood samples were collected to measure levels of glucose, insulin, haemoglobin A1c, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, free fatty acid, triglyceride, adiponectin, and high-sensitivity C-reactive protein. Muscle strength was assessed as maximal voluntary contraction during isometric knee extension. Muscle cross-sectional area in the vastus lateralis was measured using magnetic resonance imaging. Specific force (N cm-2) indicating force generation capacity was calculated as muscle strength (N) divided by the muscle cross-sectional area of the vastus lateralis (cm2). The intramyocellular lipid content was similar in both muscles in both groups. The intramyocellular lipid content in the biceps femoris significantly correlated with serum free fatty acid levels (r = 0·62, P

Original languageEnglish
JournalClinical Physiology and Functional Imaging
DOIs
Publication statusAccepted/In press - 2015
Externally publishedYes

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Quadriceps Muscle
Muscle Strength
Nonesterified Fatty Acids
Young Adult
Lipids
Muscles
Isometric Contraction
Adiponectin
C-Reactive Protein
LDL Cholesterol
HDL Cholesterol
Fasting
Knee
Hemoglobins
Triglycerides
Magnetic Resonance Spectroscopy
Cholesterol
Magnetic Resonance Imaging
Insulin
Glucose

Keywords

  • <sup>1</sup>H-magnetic resonance spectroscopy
  • Ageing
  • Biochemical profile
  • Function
  • Magnetic resonance imaging
  • Metabolism
  • Morphology

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Associations of intramyocellular lipid in vastus lateralis and biceps femoris with blood free fatty acid and muscle strength differ between young and elderly adults. / Hioki, Maya; Kanehira, Nana; Koike, Teruhiko; Saito, Akira; Takahashi, Hideyuki; Shimaoka, Kiyoshi; Sakakibara, Hisataka; Oshida, Yoshiharu; Akima, Hiroshi.

In: Clinical Physiology and Functional Imaging, 2015.

Research output: Contribution to journalArticle

Hioki, Maya ; Kanehira, Nana ; Koike, Teruhiko ; Saito, Akira ; Takahashi, Hideyuki ; Shimaoka, Kiyoshi ; Sakakibara, Hisataka ; Oshida, Yoshiharu ; Akima, Hiroshi. / Associations of intramyocellular lipid in vastus lateralis and biceps femoris with blood free fatty acid and muscle strength differ between young and elderly adults. In: Clinical Physiology and Functional Imaging. 2015.
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