Abstract
The present study aimed to determine relationships between intramyocellular lipid and biochemical profiles or muscle strength in elderly (n = 15; mean age, 71 years) and young (n = 15; mean age, 21 years) male and female adults. Levels of intramyocellular lipid in the vastus lateralis and biceps femoris muscles were determined using 1H-magnetic resonance spectroscopy. Fasting blood samples were collected to measure levels of glucose, insulin, haemoglobin A1c, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, free fatty acid, triglyceride, adiponectin, and high-sensitivity C-reactive protein. Muscle strength was assessed as maximal voluntary contraction during isometric knee extension. Muscle cross-sectional area in the vastus lateralis was measured using magnetic resonance imaging. Specific force (N cm-2) indicating force generation capacity was calculated as muscle strength (N) divided by the muscle cross-sectional area of the vastus lateralis (cm2). The intramyocellular lipid content was similar in both muscles in both groups. The intramyocellular lipid content in the biceps femoris significantly correlated with serum free fatty acid levels (r = 0·62, P
| Original language | English |
|---|---|
| Journal | Clinical Physiology and Functional Imaging |
| DOIs | |
| Publication status | Accepted/In press - 2015 |
| Externally published | Yes |
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Keywords
- <sup>1</sup>H-magnetic resonance spectroscopy
- Ageing
- Biochemical profile
- Function
- Magnetic resonance imaging
- Metabolism
- Morphology
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Associations of intramyocellular lipid in vastus lateralis and biceps femoris with blood free fatty acid and muscle strength differ between young and elderly adults. / Hioki, Maya; Kanehira, Nana; Koike, Teruhiko; Saito, Akira; Takahashi, Hideyuki; Shimaoka, Kiyoshi; Sakakibara, Hisataka; Oshida, Yoshiharu; Akima, Hiroshi.
In: Clinical Physiology and Functional Imaging, 2015.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Associations of intramyocellular lipid in vastus lateralis and biceps femoris with blood free fatty acid and muscle strength differ between young and elderly adults
AU - Hioki, Maya
AU - Kanehira, Nana
AU - Koike, Teruhiko
AU - Saito, Akira
AU - Takahashi, Hideyuki
AU - Shimaoka, Kiyoshi
AU - Sakakibara, Hisataka
AU - Oshida, Yoshiharu
AU - Akima, Hiroshi
PY - 2015
Y1 - 2015
N2 - The present study aimed to determine relationships between intramyocellular lipid and biochemical profiles or muscle strength in elderly (n = 15; mean age, 71 years) and young (n = 15; mean age, 21 years) male and female adults. Levels of intramyocellular lipid in the vastus lateralis and biceps femoris muscles were determined using 1H-magnetic resonance spectroscopy. Fasting blood samples were collected to measure levels of glucose, insulin, haemoglobin A1c, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, free fatty acid, triglyceride, adiponectin, and high-sensitivity C-reactive protein. Muscle strength was assessed as maximal voluntary contraction during isometric knee extension. Muscle cross-sectional area in the vastus lateralis was measured using magnetic resonance imaging. Specific force (N cm-2) indicating force generation capacity was calculated as muscle strength (N) divided by the muscle cross-sectional area of the vastus lateralis (cm2). The intramyocellular lipid content was similar in both muscles in both groups. The intramyocellular lipid content in the biceps femoris significantly correlated with serum free fatty acid levels (r = 0·62, P
AB - The present study aimed to determine relationships between intramyocellular lipid and biochemical profiles or muscle strength in elderly (n = 15; mean age, 71 years) and young (n = 15; mean age, 21 years) male and female adults. Levels of intramyocellular lipid in the vastus lateralis and biceps femoris muscles were determined using 1H-magnetic resonance spectroscopy. Fasting blood samples were collected to measure levels of glucose, insulin, haemoglobin A1c, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, free fatty acid, triglyceride, adiponectin, and high-sensitivity C-reactive protein. Muscle strength was assessed as maximal voluntary contraction during isometric knee extension. Muscle cross-sectional area in the vastus lateralis was measured using magnetic resonance imaging. Specific force (N cm-2) indicating force generation capacity was calculated as muscle strength (N) divided by the muscle cross-sectional area of the vastus lateralis (cm2). The intramyocellular lipid content was similar in both muscles in both groups. The intramyocellular lipid content in the biceps femoris significantly correlated with serum free fatty acid levels (r = 0·62, P
KW - <sup>1</sup>H-magnetic resonance spectroscopy
KW - Ageing
KW - Biochemical profile
KW - Function
KW - Magnetic resonance imaging
KW - Metabolism
KW - Morphology
UR - http://www.scopus.com/inward/record.url?scp=84930608739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930608739&partnerID=8YFLogxK
U2 - 10.1111/cpf.12250
DO - 10.1111/cpf.12250
M3 - Article
C2 - 26053259
AN - SCOPUS:84930608739
JO - Clinical Physiology and Functional Imaging
JF - Clinical Physiology and Functional Imaging
SN - 1475-0961
ER -