Astaxanthin production in a model cyanobacterium synechocystis sp. PCC 6803

Naoya Shimada, Yukiko Okuda, Kaisei Maeda, Daisuke Umeno, Shinichi Takaichi, Masahiko Ikeuchi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Heterologous production of a useful carotenoid astaxanthin was achieved in a cyanobacterium Synechocystis sp. PCC 6803 with the aid of marine bacterial genes. Astaxanthin and its intermediates emerged at high levels, whereas β-carotene and zeaxanthin disappeared in the strain. Total carote-noid accumulation was nearly two fold compared with wild type. The astaxanthin-producing strain was capable of only growing heterotrophically, which was likely due to the absence of β-carotene. Further enhanced accumulation was pursued by gene overexpression for possible rate-limiting steps in the biosynthesis pathway.

Original languageEnglish
Pages (from-to)116-120
Number of pages5
JournalJournal of General and Applied Microbiology
Volume66
Issue number2
DOIs
Publication statusPublished - 2020
Externally publishedYes

Keywords

  • Astaxanthin
  • Cyanobacteria
  • Metabolic engineering
  • Phototrophic grow

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

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