Asymmetric autocatalysis of 5-carbamoyl-3-pyridyl alkanols with amplification of enantiomeric excess

Shigehisa Tanji, Yasutaka Kodaka, Atsushi Ohno, Takanori Shibata, Itaru Sato, Kenso Soai

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

5-Carbamoyl-3-pyridyl alkanols with low e.e. act as asymmetric autocatalysts in the consecutive asymmetric autocatalytic addition of diisopropylzinc to 5-carbamoyl-3-pyridinecarbaldehydes. The e.e. of pyridyl alkanol amplified up to 88% e.e. without the need for any other chiral auxiliary. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)4249-4253
Number of pages5
JournalTetrahedron Asymmetry
Volume11
Issue number21
DOIs
Publication statusPublished - 2000 Nov 3
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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