5-Carbamoyl-3-pyridyl alkanols with low e.e. act as asymmetric autocatalysts in the consecutive asymmetric autocatalytic addition of diisopropylzinc to 5-carbamoyl-3-pyridinecarbaldehydes. The e.e. of pyridyl alkanol amplified up to 88% e.e. without the need for any other chiral auxiliary. (C) 2000 Elsevier Science Ltd.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry