Asymmetric rotational stroke in mouse node cilia during left-right determination

Atsuko Takamatsu, Takuji Ishikawa, Kyosuke Shinohara, Hiroshi Hamada

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Rotational movement of isolated single cilia in mice embryo was investigated, which generates leftward fluid flow in the node cavity and plays an important role in left-right determination. The leftward unidirectional flow results from tilting of the rotational axis of the cilium to the posterior side. By combining computational fluid dynamics with experimental observations, we demonstrate that the leftward stroke can be more effective than expected for cases in which cilia tilting alone is considered with the no-slip condition under constant driving torque. Our results suggest that the driving torque is asymmetric.

Original languageEnglish
Article number050701
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume87
Issue number5
DOIs
Publication statusPublished - 2013 May 15

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

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