Asymmetric rotational stroke in mouse node cilia during left-right determination

Atsuko Takamatsu, Takuji Ishikawa, Kyosuke Shinohara, Hiroshi Hamada

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    Rotational movement of isolated single cilia in mice embryo was investigated, which generates leftward fluid flow in the node cavity and plays an important role in left-right determination. The leftward unidirectional flow results from tilting of the rotational axis of the cilium to the posterior side. By combining computational fluid dynamics with experimental observations, we demonstrate that the leftward stroke can be more effective than expected for cases in which cilia tilting alone is considered with the no-slip condition under constant driving torque. Our results suggest that the driving torque is asymmetric.

    Original languageEnglish
    Article number050701
    JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
    Volume87
    Issue number5
    DOIs
    Publication statusPublished - 2013 May 15

    Fingerprint

    Tilting
    strokes
    Stroke
    Torque
    mice
    torque
    Mouse
    Slip Condition
    embryos
    Vertex of a graph
    Embryo
    computational fluid dynamics
    Computational Fluid Dynamics
    fluid flow
    Fluid Flow
    Cavity
    slip
    cavities
    Demonstrate
    Observation

    ASJC Scopus subject areas

    • Condensed Matter Physics
    • Statistical and Nonlinear Physics
    • Statistics and Probability

    Cite this

    Asymmetric rotational stroke in mouse node cilia during left-right determination. / Takamatsu, Atsuko; Ishikawa, Takuji; Shinohara, Kyosuke; Hamada, Hiroshi.

    In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, Vol. 87, No. 5, 050701, 15.05.2013.

    Research output: Contribution to journalArticle

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