Asymmetric synthesis of 3-quinolylalkylamine by enantioselective alkylation of w-diphenyl-phosphinyl-3-quinolylimine using chiral β-amino alcohols

Tadakatsu Hayase, Shunji Osanai, Takanori Shibata, Kenso Soai

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Chiral N-diphenylphosphiny 1-3-quinoly lamines (DPP amines) with up to 74.9% e.e. were obtained by the enantioselective alkylation using dialkylzincs in the presence of various chiral amino alcohols. The acidic hydrolysis of the chiral DPP amine afforded optically active chiral 3-quinolylamine without racemization.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalHeterocycles
Volume48
Issue number1
Publication statusPublished - 1998
Externally publishedYes

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Amino Alcohols
Alkylation
Amines
Hydrolysis
diphenyl

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Asymmetric synthesis of 3-quinolylalkylamine by enantioselective alkylation of w-diphenyl-phosphinyl-3-quinolylimine using chiral β-amino alcohols. / Hayase, Tadakatsu; Osanai, Shunji; Shibata, Takanori; Soai, Kenso.

In: Heterocycles, Vol. 48, No. 1, 1998, p. 139-144.

Research output: Contribution to journalArticle

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