Asymmetric synthesis of 3-quinolylalkylamine by enantioselective alkylation of w-diphenyl-phosphinyl-3-quinolylimine using chiral β-amino alcohols

Tadakatsu Hayase, Shunji Osanai, Takanori Shibata, Kenso Soai

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Chiral N-diphenylphosphiny 1-3-quinoly lamines (DPP amines) with up to 74.9% e.e. were obtained by the enantioselective alkylation using dialkylzincs in the presence of various chiral amino alcohols. The acidic hydrolysis of the chiral DPP amine afforded optically active chiral 3-quinolylamine without racemization.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalHeterocycles
Volume48
Issue number1
DOIs
Publication statusPublished - 1998 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Asymmetric synthesis of 3-quinolylalkylamine by enantioselective alkylation of w-diphenyl-phosphinyl-3-quinolylimine using chiral β-amino alcohols'. Together they form a unique fingerprint.

  • Cite this