Optically active fluorine-containing alcohols with up to 97% enantiomeric excess were synthesized by the enantioselective addition of dialkylzincs to fluorine-containing aldehydes using chiral β-aminoalcohol catalysts such as N,N-dibutylnorephedrine (DBNE, 2d), 2-morpholino-1-phenyl-1-propanol (2g, MOPEP) and diphenyl(1-methylpyrrolidin-2-yl)methanol (3, DPMPM).
- Asymmetric synthesis
- Catalytic enantioselective alkylation
ASJC Scopus subject areas
- Environmental Chemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry