Asymmetric synthesis of optically active fluorine-containing alcohols by the catalytic enantioselective alkylation of aldehydes

Tadakatsu Hayase, Tadashi Sugiyama, Masanori Suzuki, Takanori Shibata, Kenso Soai

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Optically active fluorine-containing alcohols with up to 97% enantiomeric excess were synthesized by the enantioselective addition of dialkylzincs to fluorine-containing aldehydes using chiral β-aminoalcohol catalysts such as N,N-dibutylnorephedrine (DBNE, 2d), 2-morpholino-1-phenyl-1-propanol (2g, MOPEP) and diphenyl(1-methylpyrrolidin-2-yl)methanol (3, DPMPM).

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalJournal of Fluorine Chemistry
Issue number1
Publication statusPublished - 1997 Aug 31



  • Aldehydes
  • Asymmetric synthesis
  • Catalytic enantioselective alkylation

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Chemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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